Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 854944..855367 Replicon chromosome
Accession NZ_CP011526
Organism Staphylococcus aureus strain DSM 20231

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag AA076_RS04275 Protein ID WP_001836226.1
Coordinates 854944..855195 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AA076_RS04280 Protein ID WP_000028421.1
Coordinates 855185..855367 (+) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AA076_RS16035 850497..850646 + 150 WP_001081076.1 hypothetical protein -
AA076_RS04220 850639..850920 - 282 WP_000414755.1 hypothetical protein -
AA076_RS04225 850986..851756 + 771 WP_001836222.1 conserved phage C-terminal domain-containing protein -
AA076_RS04230 851766..852545 + 780 WP_000803062.1 ATP-binding protein -
AA076_RS14640 852539..852697 + 159 WP_000256589.1 hypothetical protein -
AA076_RS04240 852710..852931 + 222 WP_001123695.1 DUF3269 family protein -
AA076_RS04245 852941..853345 + 405 WP_001836225.1 DUF1064 domain-containing protein -
AA076_RS04250 853350..853535 + 186 WP_001187243.1 DUF3113 family protein -
AA076_RS04255 853536..853841 + 306 WP_000101252.1 hypothetical protein -
AA076_RS04260 853969..854325 + 357 WP_000029376.1 hypothetical protein -
AA076_RS04265 854329..854571 + 243 WP_001562543.1 phage protein -
AA076_RS04270 854580..854951 + 372 WP_001557190.1 hypothetical protein -
AA076_RS04275 854944..855195 + 252 WP_001836226.1 DUF1024 family protein Toxin
AA076_RS04280 855185..855367 + 183 WP_000028421.1 hypothetical protein Antitoxin
AA076_RS04285 855360..855890 + 531 WP_000185651.1 dUTP pyrophosphatase -
AA076_RS04290 855927..856133 + 207 WP_000195785.1 DUF1381 domain-containing protein -
AA076_RS04295 856130..856324 + 195 WP_000132920.1 hypothetical protein -
AA076_RS04300 856321..856524 + 204 WP_001072794.1 hypothetical protein -
AA076_RS04305 856517..856690 + 174 WP_001657250.1 transcriptional activator RinB -
AA076_RS14645 856691..856837 + 147 WP_000990005.1 hypothetical protein -
AA076_RS04315 856861..857283 + 423 WP_000162701.1 RinA family phage transcriptional activator -
AA076_RS04320 857471..857965 + 495 WP_001038244.1 terminase small subunit -
AA076_RS04325 857968..859263 + 1296 WP_001836232.1 PBSX family phage terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 839710..884787 45077


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9457.35 Da        Isoelectric Point: 3.8049

>T54466 WP_001836226.1 NZ_CP011526:854944-855195 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGLPNAMQDALKEDIYLDEAVGIMTGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T54466 NZ_CP011526:854944-855195 [Staphylococcus aureus]
ATGAATAACCGTGAACAAATAGAACAGTCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTGTATAAGAAAGCACAAGCGTTTGATGAAATACTTGAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTTATCTTGATGAAGCAGTAGGGATTATGACGGGTCAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGCATTAG

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6683.59 Da        Isoelectric Point: 4.3791

>AT54466 WP_000028421.1 NZ_CP011526:855185-855367 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEAQEND

Download         Length: 183 bp

>AT54466 NZ_CP011526:855185-855367 [Staphylococcus aureus]
ATGAGCATTAGTGTAGGAGACAAGGTTTTTAATCCAGAAACAAATTCAACTTTAGAAATTGTACAACTTGTTGGCGATAT
TAGAGACACGCATTACAAGTTATCTGACGGATCTATTATTAGTCTTATAGACTTTGTTGTTAAACCAATTCATTTAATCA
AGGAGGCACAGGAAAATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References