Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4284635..4285335 Replicon chromosome
Accession NZ_CP011525
Organism Pseudomonas sp. JY-Q

Toxin (Protein)


Gene name mqsR Uniprot ID A0A173HI12
Locus tag AA098_RS19290 Protein ID WP_064614922.1
Coordinates 4285039..4285335 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID I7AUJ7
Locus tag AA098_RS19285 Protein ID WP_003254235.1
Coordinates 4284635..4285036 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AA098_RS19265 4279756..4280577 - 822 WP_003254229.1 transporter substrate-binding domain-containing protein -
AA098_RS19270 4280653..4281594 - 942 WP_004573654.1 FAD-binding protein -
AA098_RS19275 4281596..4282345 - 750 WP_003254232.1 electron transfer flavoprotein subunit beta/FixA family protein -
AA098_RS19280 4282881..4284563 + 1683 WP_010954959.1 electron transfer flavoprotein-ubiquinone oxidoreductase -
AA098_RS19285 4284635..4285036 - 402 WP_003254235.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
AA098_RS19290 4285039..4285335 - 297 WP_064614922.1 type II toxin-antitoxin system MqsR family toxin Toxin
AA098_RS19295 4285430..4286755 - 1326 WP_064614923.1 MFS transporter -
AA098_RS19300 4286828..4287307 - 480 WP_003254240.1 hypothetical protein -
AA098_RS19305 4287476..4287952 - 477 WP_064614924.1 sigma-70 family RNA polymerase sigma factor -
AA098_RS19310 4288074..4289699 - 1626 WP_003254243.1 twin-arginine translocation signal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(6-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(74-109)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10981.02 Da        Isoelectric Point: 10.2270

>T54462 WP_064614922.1 NZ_CP011525:c4285335-4285039 [Pseudomonas sp. JY-Q]
MEKRMPNCPLERVKALAAARRIRPTGAALKGAKALGMDFPGMLEVITSLKRTDFYKSMTSHIDHRVGQDVYRPLTAIGYV
YLKLSVVDDVLIVSFKEL

Download         Length: 297 bp

>T54462 NZ_CP011525:c4285335-4285039 [Pseudomonas sp. JY-Q]
ATGGAAAAGAGAATGCCTAATTGCCCGCTGGAGCGGGTAAAAGCCCTGGCTGCGGCAAGGCGAATCCGCCCTACGGGTGC
TGCATTGAAAGGCGCCAAGGCGCTGGGAATGGATTTTCCGGGCATGCTTGAGGTGATCACCAGCTTGAAGCGCACTGATT
TCTACAAGAGCATGACCAGCCATATTGACCACCGGGTTGGGCAGGATGTGTATCGCCCGCTTACAGCAATTGGGTACGTT
TATTTGAAATTGTCCGTGGTAGACGACGTGCTCATCGTGTCTTTCAAGGAGTTGTAA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14684.76 Da        Isoelectric Point: 4.9531

>AT54462 WP_003254235.1 NZ_CP011525:c4285036-4284635 [Pseudomonas sp. JY-Q]
MRCPICGGSELAPDIQGMPYSYKGEMTVIPEVSGDYCSACGECVLSHDEAMRVSHLMTAFERQVNANVVDPSFIASIRRK
FDLDQREAGEIFGGGVNAFSRYENGKTTPPVALVKLLKLLDRHPELFEEVRTA

Download         Length: 402 bp

>AT54462 NZ_CP011525:c4285036-4284635 [Pseudomonas sp. JY-Q]
ATGAGATGTCCAATATGCGGCGGCTCGGAGCTTGCACCTGACATTCAGGGCATGCCCTATAGCTACAAAGGCGAGATGAC
AGTGATCCCTGAGGTAAGTGGCGATTACTGCTCCGCATGTGGTGAATGTGTACTGAGTCATGATGAAGCCATGCGTGTCA
GTCACTTGATGACGGCATTCGAGCGCCAGGTCAACGCAAATGTTGTGGATCCTTCCTTTATTGCCTCCATACGCAGAAAG
TTCGACCTCGACCAGCGTGAAGCGGGGGAAATCTTCGGTGGTGGGGTCAATGCGTTCTCCCGTTATGAAAACGGCAAGAC
CACACCGCCAGTGGCGTTGGTGAAACTGCTCAAGCTGCTGGATCGCCATCCAGAACTCTTTGAGGAAGTGCGTACTGCCT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A173HI12

Antitoxin

Source ID Structure
AlphaFold DB I7AUJ7

References