Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 393244..393892 Replicon chromosome
Accession NZ_CP011510
Organism Mycobacterium tuberculosis strain Beijing

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag TM57_RS01860 Protein ID WP_003899414.1
Coordinates 393569..393892 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag TM57_RS01855 Protein ID WP_003899415.1
Coordinates 393244..393489 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TM57_RS01815 388392..388625 - 234 WP_003413717.1 hypothetical protein -
TM57_RS01820 388724..388996 - 273 WP_003900544.1 hypothetical protein -
TM57_RS20570 388902..389291 + 390 WP_079121809.1 hypothetical protein -
TM57_RS01825 389288..389515 + 228 WP_003899421.1 hypothetical protein -
TM57_RS01830 389660..390787 + 1128 WP_003899420.1 site-specific integrase -
TM57_RS01835 390790..391152 + 363 WP_003900543.1 hypothetical protein -
TM57_RS01840 391169..391429 + 261 WP_003899418.1 helix-turn-helix domain-containing protein -
TM57_RS01845 391426..391818 + 393 WP_003899417.1 DUF2742 domain-containing protein -
TM57_RS01850 391820..393247 + 1428 WP_003899416.1 DUF3631 domain-containing protein -
TM57_RS01855 393244..393489 + 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
TM57_RS01860 393569..393892 + 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
TM57_RS20575 394059..394550 + 492 WP_003900541.1 phage terminase small subunit P27 family -
TM57_RS01870 394703..395236 + 534 WP_003899412.1 HK97 family phage prohead protease -
TM57_RS01875 395244..396683 + 1440 WP_003901443.1 phage major capsid protein -
TM57_RS01880 396854..397105 - 252 WP_003908028.1 hypothetical protein -
TM57_RS01885 397093..397557 - 465 WP_003900539.1 ParB N-terminal domain-containing protein -
TM57_RS01890 397571..398569 - 999 WP_003900538.1 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 389660..398569 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T54379 WP_003899414.1 NZ_CP011510:393569-393892 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T54379 NZ_CP011510:393569-393892 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT54379 WP_003899415.1 NZ_CP011510:393244-393489 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT54379 NZ_CP011510:393244-393489 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References