Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 5647442..5648096 Replicon chromosome
Accession NZ_CP011507
Organism Pseudomonas trivialis strain IHBB745

Toxin (Protein)


Gene name higB Uniprot ID A0A0H5AGD8
Locus tag AA957_RS25675 Protein ID WP_049713533.1
Coordinates 5647746..5648096 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0H5ADX5
Locus tag AA957_RS25670 Protein ID WP_049712663.1
Coordinates 5647442..5647756 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AA957_RS25635 5642646..5643776 + 1131 Protein_5111 MFS transporter -
AA957_RS25640 5643818..5644258 + 441 WP_049713532.1 MEKHLA domain-containing protein -
AA957_RS25645 5644255..5644776 - 522 WP_049712658.1 DUF3087 domain-containing protein -
AA957_RS31215 5644890..5645066 + 177 WP_167345850.1 hypothetical protein -
AA957_RS25650 5645081..5645281 + 201 WP_049712659.1 hypothetical protein -
AA957_RS25655 5645313..5645549 - 237 WP_049712660.1 hypothetical protein -
AA957_RS25660 5645670..5646503 + 834 WP_049712661.1 arylamine N-acetyltransferase -
AA957_RS25665 5646628..5647380 + 753 WP_049712662.1 outer membrane beta-barrel protein -
AA957_RS25670 5647442..5647756 - 315 WP_049712663.1 XRE family transcriptional regulator Antitoxin
AA957_RS25675 5647746..5648096 - 351 WP_049713533.1 toxin Toxin
AA957_RS25680 5648335..5649798 - 1464 WP_049712664.1 NADH-quinone oxidoreductase subunit NuoN -
AA957_RS25685 5649806..5651338 - 1533 WP_049712665.1 NADH-quinone oxidoreductase subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13799.68 Da        Isoelectric Point: 9.3839

>T54369 WP_049713533.1 NZ_CP011507:c5648096-5647746 [Pseudomonas trivialis]
MDALFIELPAFERHRKDYLSDELFHGFQQELMKNPEAGDVIEGTGGLRKVRFVDERRNKGKRGGLRVIYYWWSGGTQFWL
FTLYGKHEQDDLTPQHKKALKHMLDREIKARTHHET

Download         Length: 351 bp

>T54369 NZ_CP011507:c5648096-5647746 [Pseudomonas trivialis]
ATGGATGCTCTATTTATCGAACTGCCGGCCTTCGAGCGGCATCGCAAGGACTATCTGAGTGACGAGCTTTTCCACGGTTT
TCAACAGGAGTTGATGAAGAACCCGGAAGCAGGAGACGTGATCGAGGGAACAGGCGGGTTACGCAAGGTTCGCTTTGTCG
ACGAACGACGCAACAAAGGCAAGCGCGGTGGCCTGCGGGTCATTTACTACTGGTGGTCGGGCGGCACGCAATTCTGGTTA
TTCACCCTGTACGGCAAACACGAACAGGACGACCTGACGCCACAGCACAAAAAAGCCCTAAAACACATGCTGGACAGGGA
AATCAAAGCGAGAACACATCATGAAACGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11764.54 Da        Isoelectric Point: 10.4450

>AT54369 WP_049712663.1 NZ_CP011507:c5647756-5647442 [Pseudomonas trivialis]
MKREIFSELVEGFDALANERQGKVTLRTHKVHLNHLEPLTAEEVVAVRQQLNLSRAVFAMYLRTNTRTLENWEQGRAKPN
AQAATLIRLVARFPETVAQLAALG

Download         Length: 315 bp

>AT54369 NZ_CP011507:c5647756-5647442 [Pseudomonas trivialis]
ATGAAACGTGAAATCTTTTCCGAACTGGTCGAAGGCTTCGACGCCTTGGCAAACGAACGCCAAGGCAAAGTCACCCTGCG
GACCCACAAGGTTCATCTCAACCACCTGGAGCCGCTCACCGCAGAGGAAGTGGTCGCCGTGCGTCAACAGCTCAACCTCT
CCCGTGCGGTCTTCGCCATGTACCTGCGCACCAACACGCGTACGCTGGAGAACTGGGAGCAAGGCCGGGCCAAACCCAAC
GCTCAGGCCGCCACCCTGATTCGCCTGGTGGCGCGTTTTCCTGAGACCGTGGCGCAACTTGCTGCCTTGGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H5AGD8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H5ADX5

References