Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2697620..2698320 Replicon chromosome
Accession NZ_CP011504
Organism Burkholderia pyrrocinia strain DSM 10685

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0G3X296
Locus tag ABD05_RS28160 Protein ID WP_047903229.1
Coordinates 2698024..2698320 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID A0A0G3X002
Locus tag ABD05_RS28155 Protein ID WP_047903228.1
Coordinates 2697620..2698021 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABD05_RS28135 2693287..2694639 - 1353 WP_047903224.1 LLM class flavin-dependent oxidoreductase -
ABD05_RS28140 2694647..2695696 - 1050 WP_047903225.1 LLM class flavin-dependent oxidoreductase -
ABD05_RS28145 2695748..2696689 - 942 WP_047903226.1 ABC transporter substrate-binding protein -
ABD05_RS28150 2696744..2697304 - 561 WP_047903227.1 GNAT family N-acetyltransferase -
ABD05_RS28155 2697620..2698021 - 402 WP_047903228.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
ABD05_RS28160 2698024..2698320 - 297 WP_047903229.1 type II toxin-antitoxin system MqsR family toxin Toxin
ABD05_RS28165 2698429..2699463 - 1035 WP_047903230.1 succinylglutamate desuccinylase/aspartoacylase family protein -
ABD05_RS28175 2699810..2700085 - 276 WP_047903232.1 hypothetical protein -
ABD05_RS28180 2700343..2701893 - 1551 WP_047903233.1 sensor domain-containing diguanylate cyclase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-46)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11247.15 Da        Isoelectric Point: 8.9573

>T54359 WP_047903229.1 NZ_CP011504:c2698320-2698024 [Burkholderia pyrrocinia]
MEKRRPHCKLPLVKALVESGKVRLTTSAVLGARQLGFTEREALDVVMSLTDLDFHKSMTTYADHTIWQDVYRPLTVRGDV
YLKLTVIDEVLIVSFKER

Download         Length: 297 bp

>T54359 NZ_CP011504:c2698320-2698024 [Burkholderia pyrrocinia]
ATGGAAAAGAGAAGGCCTCATTGCAAGCTGCCCCTCGTCAAGGCGCTGGTCGAATCCGGCAAGGTCCGGTTGACCACGAG
CGCAGTACTCGGCGCCCGGCAACTGGGTTTCACGGAAAGGGAGGCGCTCGATGTCGTGATGTCGCTGACCGACCTCGACT
TCCACAAGAGCATGACGACGTACGCCGACCACACGATCTGGCAGGACGTCTACCGGCCGTTGACGGTGCGTGGCGACGTG
TACCTGAAACTGACGGTGATCGACGAGGTGCTGATCGTGTCTTTCAAGGAGCGATGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14619.91 Da        Isoelectric Point: 8.8304

>AT54359 WP_047903228.1 NZ_CP011504:c2698021-2697620 [Burkholderia pyrrocinia]
MKCPACGAAKLVRDTRDIPYTYKGRSTVVRDITGDFCPACGESVLDLDEATRLGEAIAEFNKQVNATIVDPKYIAKVRKK
LRLDQREAAELFGGGVNAFSRYETGKTNPPLALVKLLKILDRHPDLLAEVRAA

Download         Length: 402 bp

>AT54359 NZ_CP011504:c2698021-2697620 [Burkholderia pyrrocinia]
ATGAAGTGTCCTGCATGCGGTGCCGCCAAGCTGGTCCGCGACACGCGAGACATCCCTTATACCTACAAGGGCCGGTCGAC
TGTCGTCCGCGATATCACCGGCGATTTCTGCCCGGCCTGCGGGGAATCGGTACTGGATCTCGACGAGGCGACCCGTCTCG
GCGAAGCGATCGCCGAGTTCAACAAGCAGGTGAACGCAACCATCGTCGACCCGAAGTACATCGCGAAGGTGCGCAAGAAG
CTGAGGCTGGATCAGCGCGAGGCGGCCGAGCTCTTCGGCGGCGGCGTCAACGCGTTCTCCCGTTACGAGACAGGCAAGAC
GAATCCGCCGCTTGCCCTCGTGAAATTGCTGAAGATCCTGGATCGTCACCCCGATCTACTCGCCGAAGTCCGAGCGGCAT
AA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0G3X296

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3X002

References