54352

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 307354..307947 Replicon chromosome
Accession NZ_CP011504
Organism Burkholderia pyrrocinia strain DSM 10685

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ABD05_RS17710 Protein ID WP_047901478.1
Coordinates 307354..307632 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0G3WX68
Locus tag ABD05_RS17715 Protein ID WP_047901479.1
Coordinates 307645..307947 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABD05_RS17690 302898..304331 - 1434 WP_047901475.1 aldehyde dehydrogenase family protein -
ABD05_RS17695 304361..306001 - 1641 WP_047901476.1 acetolactate synthase large subunit -
ABD05_RS17700 306331..306669 + 339 WP_047901477.1 type II toxin-antitoxin system RelE/ParE family toxin -
ABD05_RS17705 306673..306972 + 300 WP_039344756.1 putative addiction module antidote protein -
ABD05_RS17710 307354..307632 + 279 WP_047901478.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ABD05_RS17715 307645..307947 + 303 WP_047901479.1 HigA family addiction module antidote protein Antitoxin
ABD05_RS17720 307981..309267 - 1287 WP_047901480.1 DUF445 domain-containing protein -
ABD05_RS17725 309479..310699 - 1221 WP_047901481.1 FAD-dependent oxidoreductase -
ABD05_RS17730 310689..311015 - 327 WP_034185113.1 non-heme iron oxygenase ferredoxin subunit -
ABD05_RS17735 311033..311509 - 477 WP_014900133.1 aromatic-ring-hydroxylating dioxygenase subunit beta -
ABD05_RS17740 311524..312795 - 1272 WP_047903620.1 Rieske 2Fe-2S domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-81)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10657.13 Da        Isoelectric Point: 8.5441

>T54352 WP_047901478.1 NZ_CP011504:307354-307632 [Burkholderia pyrrocinia]
MIRSFRCKDTQLLFAGESPKRFRTIETVATRKLQMVAAAKELRDLRAPPGNRLEALQGDRGGQHSIRINEQWRICFEWSD
DGPTQVEIVDYH

Download         Length: 279 bp

>T54352 NZ_CP011504:307354-307632 [Burkholderia pyrrocinia]
ATGATCAGATCGTTCCGATGCAAGGATACCCAGTTGCTGTTTGCTGGAGAATCGCCCAAGCGCTTCCGCACGATCGAAAC
CGTTGCCACCCGGAAACTGCAAATGGTCGCCGCTGCGAAAGAACTGCGCGATTTGCGGGCGCCTCCCGGCAACCGGCTCG
AGGCGTTGCAAGGCGATCGGGGAGGCCAGCACAGCATCCGCATCAACGAGCAATGGCGGATCTGTTTCGAATGGAGCGAC
GATGGCCCCACCCAGGTCGAGATCGTCGACTATCACTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11556.34 Da        Isoelectric Point: 8.5562

>AT54352 WP_047901479.1 NZ_CP011504:307645-307947 [Burkholderia pyrrocinia]
MLKNGMRPIHPGEVLREEFLVPLEMSVNALALALNVPATRLHEIVKERRGITADTAYRLARYFDTSPEFWLNLQAAYDLK
TLPTRSEIDRKVEPRERTHA

Download         Length: 303 bp

>AT54352 NZ_CP011504:307645-307947 [Burkholderia pyrrocinia]
ATGCTCAAGAATGGAATGCGCCCGATTCATCCGGGCGAGGTCCTGCGGGAAGAGTTCCTCGTTCCGCTGGAAATGAGCGT
CAACGCACTGGCGCTCGCGTTGAACGTGCCGGCGACACGCTTGCACGAAATCGTCAAGGAACGGCGCGGCATCACGGCCG
ATACGGCTTACCGGCTTGCGCGCTACTTCGATACGTCGCCGGAATTCTGGTTGAACCTGCAAGCCGCTTACGATCTCAAG
ACACTGCCGACGCGCAGCGAGATCGACCGCAAGGTCGAACCGCGCGAGCGCACGCACGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3WX68

References