Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 2523575..2523797 Replicon chromosome
Accession NZ_CP011495
Organism Escherichia coli strain NCM3722 isolate K-12

Toxin (Protein)


Gene name ldrD Uniprot ID D3H2K1
Locus tag AA953_RS12590 Protein ID WP_000170955.1
Coordinates 2523575..2523682 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 2523730..2523797 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AA953_RS12560 2519431..2520264 + 834 WP_000456467.1 peptide chain release factor N(5)-glutamine methyltransferase -
AA953_RS12565 2520261..2520653 + 393 WP_000200374.1 invasion regulator SirB2 -
AA953_RS12570 2520657..2521466 + 810 WP_001257044.1 invasion regulator SirB1 -
AA953_RS12575 2521502..2522356 + 855 WP_000811065.1 3-deoxy-8-phosphooctulonate synthase -
AA953_RS12580 2522505..2522612 - 108 WP_000170955.1 small toxic polypeptide LdrA/LdrC -
- 2522660..2522726 + 67 NuclAT_34 - -
- 2522660..2522726 + 67 NuclAT_34 - -
- 2522660..2522726 + 67 NuclAT_34 - -
- 2522660..2522726 + 67 NuclAT_34 - -
- 2522660..2522726 + 67 NuclAT_36 - -
- 2522660..2522726 + 67 NuclAT_36 - -
- 2522660..2522726 + 67 NuclAT_36 - -
- 2522660..2522726 + 67 NuclAT_36 - -
- 2522660..2522726 + 67 NuclAT_38 - -
- 2522660..2522726 + 67 NuclAT_38 - -
- 2522660..2522726 + 67 NuclAT_38 - -
- 2522660..2522726 + 67 NuclAT_38 - -
- 2522660..2522726 + 67 NuclAT_40 - -
- 2522660..2522726 + 67 NuclAT_40 - -
- 2522660..2522726 + 67 NuclAT_40 - -
- 2522660..2522726 + 67 NuclAT_40 - -
- 2522660..2522726 + 67 NuclAT_42 - -
- 2522660..2522726 + 67 NuclAT_42 - -
- 2522660..2522726 + 67 NuclAT_42 - -
- 2522660..2522726 + 67 NuclAT_42 - -
- 2522660..2522726 + 67 NuclAT_44 - -
- 2522660..2522726 + 67 NuclAT_44 - -
- 2522660..2522726 + 67 NuclAT_44 - -
- 2522660..2522726 + 67 NuclAT_44 - -
- 2522662..2522727 + 66 NuclAT_18 - -
- 2522662..2522727 + 66 NuclAT_18 - -
- 2522662..2522727 + 66 NuclAT_18 - -
- 2522662..2522727 + 66 NuclAT_18 - -
- 2522662..2522727 + 66 NuclAT_21 - -
- 2522662..2522727 + 66 NuclAT_21 - -
- 2522662..2522727 + 66 NuclAT_21 - -
- 2522662..2522727 + 66 NuclAT_21 - -
- 2522662..2522727 + 66 NuclAT_24 - -
- 2522662..2522727 + 66 NuclAT_24 - -
- 2522662..2522727 + 66 NuclAT_24 - -
- 2522662..2522727 + 66 NuclAT_24 - -
- 2522662..2522727 + 66 NuclAT_27 - -
- 2522662..2522727 + 66 NuclAT_27 - -
- 2522662..2522727 + 66 NuclAT_27 - -
- 2522662..2522727 + 66 NuclAT_27 - -
- 2522662..2522727 + 66 NuclAT_30 - -
- 2522662..2522727 + 66 NuclAT_30 - -
- 2522662..2522727 + 66 NuclAT_30 - -
- 2522662..2522727 + 66 NuclAT_30 - -
- 2522662..2522727 + 66 NuclAT_33 - -
- 2522662..2522727 + 66 NuclAT_33 - -
- 2522662..2522727 + 66 NuclAT_33 - -
- 2522662..2522727 + 66 NuclAT_33 - -
AA953_RS12585 2523040..2523147 - 108 WP_000170963.1 small toxic polypeptide LdrB -
- 2523195..2523262 + 68 NuclAT_17 - -
- 2523195..2523262 + 68 NuclAT_17 - -
- 2523195..2523262 + 68 NuclAT_17 - -
- 2523195..2523262 + 68 NuclAT_17 - -
- 2523195..2523262 + 68 NuclAT_20 - -
- 2523195..2523262 + 68 NuclAT_20 - -
- 2523195..2523262 + 68 NuclAT_20 - -
- 2523195..2523262 + 68 NuclAT_20 - -
- 2523195..2523262 + 68 NuclAT_23 - -
- 2523195..2523262 + 68 NuclAT_23 - -
- 2523195..2523262 + 68 NuclAT_23 - -
- 2523195..2523262 + 68 NuclAT_23 - -
- 2523195..2523262 + 68 NuclAT_26 - -
- 2523195..2523262 + 68 NuclAT_26 - -
- 2523195..2523262 + 68 NuclAT_26 - -
- 2523195..2523262 + 68 NuclAT_26 - -
- 2523195..2523262 + 68 NuclAT_29 - -
- 2523195..2523262 + 68 NuclAT_29 - -
- 2523195..2523262 + 68 NuclAT_29 - -
- 2523195..2523262 + 68 NuclAT_29 - -
- 2523195..2523262 + 68 NuclAT_32 - -
- 2523195..2523262 + 68 NuclAT_32 - -
- 2523195..2523262 + 68 NuclAT_32 - -
- 2523195..2523262 + 68 NuclAT_32 - -
- 2523196..2523261 + 66 NuclAT_35 - -
- 2523196..2523261 + 66 NuclAT_35 - -
- 2523196..2523261 + 66 NuclAT_35 - -
- 2523196..2523261 + 66 NuclAT_35 - -
- 2523196..2523261 + 66 NuclAT_37 - -
- 2523196..2523261 + 66 NuclAT_37 - -
- 2523196..2523261 + 66 NuclAT_37 - -
- 2523196..2523261 + 66 NuclAT_37 - -
- 2523196..2523261 + 66 NuclAT_39 - -
- 2523196..2523261 + 66 NuclAT_39 - -
- 2523196..2523261 + 66 NuclAT_39 - -
- 2523196..2523261 + 66 NuclAT_39 - -
- 2523196..2523261 + 66 NuclAT_41 - -
- 2523196..2523261 + 66 NuclAT_41 - -
- 2523196..2523261 + 66 NuclAT_41 - -
- 2523196..2523261 + 66 NuclAT_41 - -
- 2523196..2523261 + 66 NuclAT_43 - -
- 2523196..2523261 + 66 NuclAT_43 - -
- 2523196..2523261 + 66 NuclAT_43 - -
- 2523196..2523261 + 66 NuclAT_43 - -
- 2523196..2523261 + 66 NuclAT_45 - -
- 2523196..2523261 + 66 NuclAT_45 - -
- 2523196..2523261 + 66 NuclAT_45 - -
- 2523196..2523261 + 66 NuclAT_45 - -
AA953_RS12590 2523575..2523682 - 108 WP_000170955.1 small toxic polypeptide LdrA/LdrC Toxin
- 2523730..2523797 + 68 NuclAT_16 - Antitoxin
- 2523730..2523797 + 68 NuclAT_16 - Antitoxin
- 2523730..2523797 + 68 NuclAT_16 - Antitoxin
- 2523730..2523797 + 68 NuclAT_16 - Antitoxin
- 2523730..2523797 + 68 NuclAT_19 - Antitoxin
- 2523730..2523797 + 68 NuclAT_19 - Antitoxin
- 2523730..2523797 + 68 NuclAT_19 - Antitoxin
- 2523730..2523797 + 68 NuclAT_19 - Antitoxin
- 2523730..2523797 + 68 NuclAT_22 - Antitoxin
- 2523730..2523797 + 68 NuclAT_22 - Antitoxin
- 2523730..2523797 + 68 NuclAT_22 - Antitoxin
- 2523730..2523797 + 68 NuclAT_22 - Antitoxin
- 2523730..2523797 + 68 NuclAT_25 - Antitoxin
- 2523730..2523797 + 68 NuclAT_25 - Antitoxin
- 2523730..2523797 + 68 NuclAT_25 - Antitoxin
- 2523730..2523797 + 68 NuclAT_25 - Antitoxin
- 2523730..2523797 + 68 NuclAT_28 - Antitoxin
- 2523730..2523797 + 68 NuclAT_28 - Antitoxin
- 2523730..2523797 + 68 NuclAT_28 - Antitoxin
- 2523730..2523797 + 68 NuclAT_28 - Antitoxin
- 2523730..2523797 + 68 NuclAT_31 - Antitoxin
- 2523730..2523797 + 68 NuclAT_31 - Antitoxin
- 2523730..2523797 + 68 NuclAT_31 - Antitoxin
- 2523730..2523797 + 68 NuclAT_31 - Antitoxin
AA953_RS12595 2524086..2525186 - 1101 WP_000063607.1 sodium-potassium/proton antiporter ChaA -
AA953_RS12600 2525456..2525686 + 231 WP_001146444.1 putative cation transport regulator ChaB -
AA953_RS12605 2525844..2526539 + 696 WP_001336325.1 glutathione-specific gamma-glutamylcyclotransferase -
AA953_RS12610 2526583..2526936 - 354 WP_001169669.1 DsrE/F sulfur relay family protein YchN -
AA953_RS12615 2527121..2528515 + 1395 WP_000086217.1 inverse autotransporter invasin YchO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4013.82 Da        Isoelectric Point: 11.4779

>T54316 WP_000170955.1 NZ_CP011495:c2523682-2523575 [Escherichia coli]
MTLAQFAMIFWHDLAAPILAGIITAAIVSWWRNRK

Download         Length: 108 bp

>T54316 NZ_CP011495:c2523682-2523575 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 68 bp

>AT54316 NZ_CP011495:2523730-2523797 [Escherichia coli]
GTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829J2A9

Antitoxin

Download structure file

References