Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1856099..1856577 Replicon chromosome
Accession NZ_CP011477
Organism Spongiibacter sp. IMCC21906

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IMCC21906_RS08505 Protein ID WP_082117418.1
Coordinates 1856099..1856284 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IMCC21906_RS08510 Protein ID WP_047011811.1
Coordinates 1856284..1856577 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMCC21906_RS08485 1852379..1853599 + 1221 WP_047011806.1 flagellar biosynthesis protein FlhF -
IMCC21906_RS08490 1853622..1854455 + 834 WP_047011807.1 MinD/ParA family protein -
IMCC21906_RS08495 1854452..1855180 + 729 WP_047011808.1 RNA polymerase sigma factor FliA -
IMCC21906_RS08500 1855236..1855706 + 471 WP_047011809.1 DUF2802 domain-containing protein -
IMCC21906_RS08505 1856099..1856284 + 186 WP_082117418.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IMCC21906_RS08510 1856284..1856577 + 294 WP_047011811.1 HigA family addiction module antidote protein Antitoxin
IMCC21906_RS08515 1856957..1857532 + 576 WP_047011812.1 antibiotic biosynthesis monooxygenase -
IMCC21906_RS08520 1857709..1857987 + 279 WP_047011813.1 type II toxin-antitoxin system RelE/ParE family toxin -
IMCC21906_RS08525 1857987..1858286 + 300 WP_047011814.1 HigA family addiction module antidote protein -
IMCC21906_RS16830 1858638..1858814 + 177 WP_156166019.1 hypothetical protein -
IMCC21906_RS08530 1858807..1859787 + 981 WP_052763450.1 sigma-54 dependent transcriptional regulator -
IMCC21906_RS08535 1859813..1860211 + 399 WP_047011815.1 flagellar hook-basal body complex protein FliE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-61)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-85)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 7117.00 Da        Isoelectric Point: 6.0431

>T54289 WP_082117418.1 NZ_CP011477:1856099-1856284 [Spongiibacter sp. IMCC21906]
MQLTALDTAYCIDDLDIPGYRLHSLKGSRKGLWSITVSGNWRVTFEFHEGHVFIVNYEDYH

Download         Length: 186 bp

>T54289 NZ_CP011477:1856099-1856284 [Spongiibacter sp. IMCC21906]
ATGCAACTTACAGCCTTGGATACTGCCTATTGTATTGACGATTTGGATATCCCGGGTTACCGACTGCACTCATTAAAAGG
TAGCCGAAAAGGTCTGTGGTCGATTACTGTCAGTGGTAACTGGCGAGTTACTTTTGAGTTTCATGAAGGCCATGTTTTTA
TCGTCAACTATGAGGATTATCATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10786.52 Da        Isoelectric Point: 8.0275

>AT54289 WP_047011811.1 NZ_CP011477:1856284-1856577 [Spongiibacter sp. IMCC21906]
MTMYNPPHPGEFIQATYMEPFDISCRNLAKHLDVAASTLNRLIKGQSGISPEMALRLAKVLGRSPESWLTMQDNYDLSVA
KKQLKLSNVLPLDLNAA

Download         Length: 294 bp

>AT54289 NZ_CP011477:1856284-1856577 [Spongiibacter sp. IMCC21906]
ATGACTATGTATAACCCCCCTCATCCTGGTGAGTTTATTCAGGCAACATATATGGAGCCCTTTGATATTAGCTGTCGCAA
TCTTGCCAAGCATCTTGATGTAGCAGCTTCAACTCTTAATAGGCTTATAAAAGGGCAGAGTGGAATCAGTCCTGAAATGG
CTTTAAGGTTGGCTAAGGTTTTAGGTCGAAGCCCAGAAAGCTGGCTTACCATGCAAGACAATTACGATTTGTCTGTTGCA
AAAAAACAGTTAAAGCTCTCCAATGTACTCCCCCTTGATTTAAATGCCGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References