Detailed information of TA system TA054285

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/MqsA(antitoxin)
• Location: 90107..90698
• Replicon: chromosome
• Accession: NZ_CP011477
• Organism: Spongiibacter sp. IMCC21906

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: IMCC21906_RS00405
• Protein ID: WP_047010500.1
• Coordinates: 90387..90698 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A0F7LYG3
• Locus tag: IMCC21906_RS00400
• Protein ID: WP_047010499.1
• Coordinates: 90107..90394 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IMCC21906_RS00380	85873..86754	+	882	WP_197085979.1	AraC family transcriptional regulator	-
IMCC21906_RS00385	86790..88076	-	1287	WP_047010496.1	NADH:flavin oxidoreductase/NADH oxidase family protein	-
IMCC21906_RS00390	88082..88483	-	402	WP_047010497.1	nuclear transport factor 2 family protein	-
IMCC21906_RS00395	88816..90006	+	1191	WP_047010498.1	class I SAM-dependent rRNA methyltransferase	-
IMCC21906_RS00400	90107..90394	-	288	WP_047010499.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
IMCC21906_RS00405	90387..90698	-	312	WP_047010500.1	transcriptional regulator	Toxin
IMCC21906_RS00410	91192..91395	+	204	WP_156165947.1	hypothetical protein	-
IMCC21906_RS00415	91451..91762	+	312	WP_197085925.1	DUF2695 domain-containing protein	-
IMCC21906_RS00420	91851..92180	+	330	WP_047010502.1	hypothetical protein	-
IMCC21906_RS00425	92334..92807	+	474	WP_047010503.1	DUF1851 domain-containing protein	-
IMCC21906_RS00430	92917..93237	+	321	WP_156165948.1	hypothetical protein	-
IMCC21906_RS00435	93461..93793	+	333	WP_197085980.1	GFA family protein	-
IMCC21906_RS00440	93865..94501	-	637	Protein_89	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (41-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 11769.56 Da
• Isoelectric Point: 9.5919

>T54285 WP_047010500.1 NZ_CP011477:c90698-90387 [Spongiibacter sp. IMCC21906]
MIFIETSVFTKLLPNYLSDENYRALQSYLMQKPDAGDIVKGSGGVRKVRWAPDGKGKSGGVRVIYYWKKPDHEIWMLTIY
SKSERSTLPGHILKQIAEAIDHE

Nucleotide

• Length: 312 bp

>T54285 NZ_CP011477:c90698-90387 [Spongiibacter sp. IMCC21906]
ATGATATTCATCGAAACCAGCGTATTTACGAAACTTCTTCCGAATTACCTTTCGGATGAAAATTATCGAGCATTGCAGAG
CTATCTCATGCAAAAGCCTGATGCTGGCGATATCGTCAAGGGCTCTGGTGGTGTAAGGAAGGTTCGCTGGGCTCCCGACG
GAAAGGGAAAAAGTGGTGGCGTTAGAGTTATCTACTATTGGAAGAAGCCTGATCATGAAATCTGGATGCTTACGATTTAT
AGCAAATCGGAGCGGTCTACGCTTCCTGGTCATATTTTGAAACAAATCGCAGAGGCAATCGATCATGAGTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10705.41 Da
• Isoelectric Point: 10.6952

>AT54285 WP_047010499.1 NZ_CP011477:c90394-90107 [Spongiibacter sp. IMCC21906]
MSKRDIGAEILSGIREIQQYKKGKVQLKTRELSEPSPPQVIRSKLKMSQSAFAGLLGVSMRTLQDWEQGRREPQGPAVAL
LRIAEQHPEVFAQLH

Nucleotide

• Length: 288 bp

>AT54285 NZ_CP011477:c90394-90107 [Spongiibacter sp. IMCC21906]
ATGAGTAAGCGAGATATCGGTGCTGAGATCCTAAGTGGCATTAGAGAAATTCAGCAGTACAAGAAAGGGAAGGTTCAATT
AAAAACCAGAGAGCTTTCGGAGCCCTCGCCACCGCAAGTGATCCGCTCAAAGCTCAAAATGTCGCAATCAGCATTTGCAG
GGTTGCTGGGTGTCAGTATGCGTACGCTGCAAGATTGGGAGCAGGGCCGCCGCGAACCACAAGGTCCGGCTGTGGCTCTT
CTTCGTATTGCGGAACAACACCCGGAAGTCTTCGCTCAACTTCACTAA

Structures

Antitoxin

• AlphaFold DB: A0A0F7LYG3