Detailed information of TA system TA054252

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HTH_XRE
• Location: 22222..22933
• Replicon: plasmid pYU39_89
• Accession: NZ_CP011430
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain YU39 isolate YUHS 05-78

Toxin (Protein)

• Gene name: higB
• Uniprot ID: I2UJZ0
• Locus tag: SE14_RS24875
• Protein ID: WP_000162415.1
• Coordinates: 22631..22933 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: SE14_RS24870
• Protein ID: WP_000806445.1
• Coordinates: 22222..22560 (-)
• Length: 113 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SE14_RS24835	17294..18205	-	912	WP_024144056.1	hypothetical protein	-
SE14_RS24840	18473..19126	+	654	WP_001557715.1	hypothetical protein	-
SE14_RS24850	19455..19784	+	330	WP_000542383.1	hypothetical protein	-
SE14_RS24855	19777..20973	+	1197	WP_022630904.1	hypothetical protein	-
SE14_RS28480	21007..21744	-	738	WP_022630905.1	hypothetical protein	-
SE14_RS24865	21806..22165	-	360	WP_022630906.1	transcriptional regulator	-
SE14_RS24870	22222..22560	-	339	WP_000806445.1	HigA family addiction module antidote protein	Antitoxin
SE14_RS24875	22631..22933	-	303	WP_000162415.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SE14_RS24880	23096..23887	+	792	WP_001557712.1	hypothetical protein	-
SE14_RS24885	23884..24651	+	768	WP_000203293.1	hypothetical protein	-
SE14_RS24890	24655..25635	+	981	WP_000046500.1	hypothetical protein	-
SE14_RS24895	25632..26285	+	654	WP_000828868.1	hypothetical protein	-
SE14_RS24900	26345..27250	+	906	WP_001258018.1	recombination-associated protein RdgC	-
SE14_RS24905	27234..27914	+	681	WP_000812238.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..88949	88949

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (7-264)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 14882.85 Da
• Isoelectric Point: 5.5500

>T54252 WP_000162415.1 NZ_CP011430:c22933-22631 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 303 bp

>T54252 NZ_CP011430:c22933-22631 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin

Protein

• Length: 113 a.a.
• Molecular weight: 16648.97 Da
• Isoelectric Point: 5.5500

>AT54252 WP_000806445.1 NZ_CP011430:c22560-22222 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 339 bp

>AT54252 NZ_CP011430:c22560-22222 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTT

Structures

Toxin

• AlphaFold DB: A0A631VBQ3