Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 14747..15404 | Replicon | plasmid pYU39_IncA/C |
| Accession | NZ_CP011429 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain YU39 isolate YUHS 05-78 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | SE14_RS23915 | Protein ID | WP_000270043.1 |
| Coordinates | 15054..15404 (-) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | SE14_RS23910 | Protein ID | WP_000124640.1 |
| Coordinates | 14747..15049 (-) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SE14_RS23860 | 10372..10800 | + | 429 | WP_000591074.1 | hypothetical protein | - |
| SE14_RS23865 | 10857..11216 | + | 360 | WP_000422768.1 | hypothetical protein | - |
| SE14_RS23870 | 11216..11662 | + | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
| SE14_RS23875 | 11659..12177 | + | 519 | WP_000210756.1 | nitrite reductase | - |
| SE14_RS23880 | 12177..12407 | + | 231 | WP_000972663.1 | hypothetical protein | - |
| SE14_RS23885 | 12394..13251 | + | 858 | WP_001167032.1 | hypothetical protein | - |
| SE14_RS23895 | 13482..14009 | + | 528 | WP_001236377.1 | thermonuclease family protein | - |
| SE14_RS23900 | 14067..14339 | + | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
| SE14_RS23905 | 14427..14720 | + | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| SE14_RS23910 | 14747..15049 | - | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| SE14_RS23915 | 15054..15404 | - | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| SE14_RS23920 | 15567..16115 | + | 549 | WP_001061574.1 | transcriptional regulator | - |
| SE14_RS27880 | 16456..16650 | + | 195 | WP_000343597.1 | hypothetical protein | - |
| SE14_RS27885 | 16661..17032 | + | 372 | WP_000516916.1 | hypothetical protein | - |
| SE14_RS23940 | 17025..17495 | + | 471 | WP_001281821.1 | hypothetical protein | - |
| SE14_RS23945 | 17510..17845 | - | 336 | WP_000683476.1 | hypothetical protein | - |
| SE14_RS23950 | 17942..18430 | + | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
| SE14_RS23955 | 18433..18930 | + | 498 | WP_000062185.1 | hypothetical protein | - |
| SE14_RS23960 | 19145..19849 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| SE14_RS23965 | 19914..20093 | - | 180 | Protein_32 | helix-turn-helix transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..156323 | 156323 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 17237.68 Da Isoelectric Point: 5.5500
>T54250 WP_000270043.1 NZ_CP011429:c15404-15054 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
Download Length: 351 bp
>T54250 NZ_CP011429:c15404-15054 [Salmonella enterica subsp. enterica serovar Typhimurium]
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Antitoxin
Download Length: 101 a.a. Molecular weight: 14882.85 Da Isoelectric Point: 5.5500
>AT54250 WP_000124640.1 NZ_CP011429:c15049-14747 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
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Download Length: 303 bp
>AT54250 NZ_CP011429:c15049-14747 [Salmonella enterica subsp. enterica serovar Typhimurium]
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Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|