Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2076505..2077024 Replicon chromosome
Accession NZ_CP011419
Organism Streptococcus suis strain NSUI002

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0K2E7Z7
Locus tag AA105_RS10460 Protein ID WP_013730620.1
Coordinates 2076505..2076762 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag AA105_RS10465 Protein ID WP_002939010.1
Coordinates 2076764..2077024 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AA105_RS10445 2072976..2074706 - 1731 WP_009910905.1 membrane protein -
AA105_RS10450 2075069..2075977 - 909 WP_074411269.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
AA105_RS10455 2075961..2076491 - 531 WP_009910909.1 DUF1697 domain-containing protein -
AA105_RS10460 2076505..2076762 - 258 WP_013730620.1 Txe/YoeB family addiction module toxin Toxin
AA105_RS10465 2076764..2077024 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AA105_RS10470 2077100..2077555 - 456 WP_013730621.1 8-oxo-dGTP diphosphatase -
AA105_RS10475 2077559..2077927 - 369 WP_013730622.1 hypothetical protein -
AA105_RS10480 2077920..2078489 - 570 WP_022540720.1 ribonuclease M5 -
AA105_RS10485 2078473..2079255 - 783 WP_002939015.1 TatD family hydrolase -
AA105_RS10490 2079363..2079500 - 138 WP_002939016.1 50S ribosomal protein L34 -
AA105_RS10495 2079668..2080663 - 996 WP_013730624.1 protein jag -
AA105_RS10500 2080683..2081495 - 813 WP_004194552.1 YidC/Oxa1 family membrane protein insertase -
AA105_RS10505 2081479..2081838 - 360 WP_013730625.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.86 Da        Isoelectric Point: 8.0279

>T54240 WP_013730620.1 NZ_CP011419:c2076762-2076505 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp

>T54240 NZ_CP011419:c2076762-2076505 [Streptococcus suis]
ATGGGAATCCATTTTACAGACGACGCCTGGGAAGACTATCTTTATTGGCAGGGTCAGGATAAGAAAACACTGAAGAGAAT
CAATAAGATTATCAAGGATATGCAGCGACATCCTTTTGAAGGCATTGCCAAACCAGAACCTTTGAAGTATGATTATCAAG
GTGCCTGGTCTCGGAGAATTGATGCGGAGAATCGGTTGATTTATATGGTGGAAGCTGATCGGTTGTGCATCCTGTCGCTA
AAGGATCATTATAGGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT54240 WP_002939010.1 NZ_CP011419:c2077024-2076764 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp

>AT54240 NZ_CP011419:c2077024-2076764 [Streptococcus suis]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAGGACTATATGAAAAAGGTCAATGACGAGTTTGAACCTTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTCTCAAAGAGTGAGTGGGATAGTTTACAAGAAACCCTCG
CTGTTGCTCGGAACACTTATCTGTCTCAAAAAGTCCTACGTGGTATGGCTAAAGTCAAAACGGGACAAACCCAAGAACGA
AACCTGATAGAGGCGGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2E7Z7

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References