Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 640436..641035 Replicon chromosome
Accession NZ_CP011379
Organism Moraxella bovoculi strain 33362

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag AAX11_RS03030 Protein ID WP_046696307.1
Coordinates 640436..640714 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag AAX11_RS03035 Protein ID WP_046696308.1
Coordinates 640730..641035 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AAX11_RS03020 636884..639735 - 2852 Protein_586 host specificity protein J -
AAX11_RS03025 639776..640351 - 576 WP_046701854.1 tail assembly protein -
AAX11_RS03030 640436..640714 + 279 WP_046696307.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AAX11_RS03035 640730..641035 + 306 WP_046696308.1 HigA family addiction module antidote protein Antitoxin
AAX11_RS03040 641007..641786 - 780 WP_046701855.1 C40 family peptidase -
AAX11_RS03045 641842..642228 - 387 WP_046696310.1 hypothetical protein -
AAX11_RS03050 642228..643001 - 774 WP_046696311.1 hypothetical protein -
AAX11_RS03055 643062..643775 - 714 WP_046696312.1 phage minor tail protein L -
AAX11_RS03060 643827..644225 - 399 WP_046696313.1 hypothetical protein -
AAX11_RS03065 644303..644632 - 330 WP_046696314.1 phage tail protein -
AAX11_RS03070 644677..644934 - 258 WP_046696315.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 632011..704321 72310


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10585.00 Da        Isoelectric Point: 5.0896

>T54180 WP_046696307.1 NZ_CP011379:640436-640714 [Moraxella bovoculi]
MIKGFKCKDTQSLFETGSSRVFSNFISVATRKLTMLDTATILADLRSPPANRLEKLTGDREGQYSIRINDQFRICFVWED
DGVYDVEIVDYH

Download         Length: 279 bp

>T54180 NZ_CP011379:640436-640714 [Moraxella bovoculi]
ATGATTAAAGGTTTTAAATGTAAAGACACCCAAAGCCTATTTGAGACAGGGTCAAGCCGTGTATTTTCTAATTTTATCTC
GGTTGCCACTCGTAAACTAACCATGCTTGATACCGCCACAATTCTTGCTGACTTACGCTCTCCACCTGCCAACCGCCTTG
AAAAACTCACAGGCGATAGAGAAGGTCAGTACAGCATTCGCATTAACGACCAATTTCGCATTTGCTTTGTGTGGGAAGAT
GATGGCGTGTACGATGTTGAGATTGTTGATTATCACTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11336.07 Da        Isoelectric Point: 7.0096

>AT54180 WP_046696308.1 NZ_CP011379:640730-641035 [Moraxella bovoculi]
MFKNGMRPVHAGEVLREEYLIPLGMSATALAKALGVTPARINDIVRQRRGITADTALRLARYFGGSPEFWLNLQMTYELR
LAQTELADSLEFISPYETAYA

Download         Length: 306 bp

>AT54180 NZ_CP011379:640730-641035 [Moraxella bovoculi]
ATGTTCAAAAATGGTATGAGACCCGTTCACGCAGGGGAGGTTTTGCGTGAAGAATATCTAATCCCACTGGGTATGTCCGC
CACTGCCTTAGCAAAGGCACTTGGTGTTACCCCCGCACGCATTAACGACATTGTGCGGCAGCGGCGTGGCATTACAGCCG
ATACCGCTTTGCGTTTGGCTCGTTATTTTGGTGGTAGTCCAGAGTTTTGGCTAAATTTGCAAATGACCTATGAACTTCGC
CTTGCCCAAACCGAACTGGCGGACAGCTTGGAGTTTATCAGTCCTTATGAAACCGCCTATGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References