Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1212572..1213147 Replicon chromosome
Accession NZ_CP011378
Organism Moraxella bovoculi strain 28389

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag AAX07_RS05970 Protein ID WP_046696629.1
Coordinates 1212893..1213147 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AAX07_RS05965 Protein ID WP_046696628.1
Coordinates 1212572..1212871 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AAX07_RS05945 1208733..1209413 - 681 WP_046702108.1 hypothetical protein -
AAX07_RS05950 1209453..1210079 - 627 WP_046696627.1 DUF262 domain-containing protein -
AAX07_RS05955 1210182..1210802 - 621 WP_080947488.1 WYL domain-containing protein -
AAX07_RS05960 1210964..1212403 + 1440 WP_155400009.1 ATP-binding protein -
AAX07_RS05965 1212572..1212871 - 300 WP_046696628.1 helix-turn-helix transcriptional regulator Antitoxin
AAX07_RS05970 1212893..1213147 - 255 WP_046696629.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AAX07_RS05975 1213427..1214818 - 1392 WP_046696630.1 class II fumarate hydratase -
AAX07_RS05980 1214951..1215514 + 564 WP_046696631.1 5-formyltetrahydrofolate cyclo-ligase -
AAX07_RS05985 1215519..1216586 - 1068 WP_046696632.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(5-77)

Antitoxin

HigA2-like, helix-turn-helix domain

(10-88)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9402.75 Da        Isoelectric Point: 8.8755

>T54178 WP_046696629.1 NZ_CP011378:c1213147-1212893 [Moraxella bovoculi]
MTSGLQQYGHRLSLPYADTLYGSKFSNMKELRIQIGGGPDRAFYTFDSIRQAIVLCAGNKVGNEKQFYKQMIPLADEFIS
TAFG

Download         Length: 255 bp

>T54178 NZ_CP011378:c1213147-1212893 [Moraxella bovoculi]
ATGACAAGTGGCTTACAACAATACGGACACCGATTATCCCTCCCTTATGCCGATACTTTATATGGCTCAAAATTTAGCAA
CATGAAAGAATTGCGTATCCAAATCGGGGGCGGCCCTGATCGTGCTTTTTATACGTTTGACTCCATACGTCAAGCGATTG
TGCTATGTGCAGGTAACAAAGTGGGCAATGAAAAGCAGTTTTATAAACAGATGATACCGCTTGCTGATGAGTTTATATCA
ACAGCATTTGGATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11295.22 Da        Isoelectric Point: 8.5370

>AT54178 WP_046696628.1 NZ_CP011378:c1212871-1212572 [Moraxella bovoculi]
MANLNDMLTKLQKERLARVQKMADEMILDYKLHQLREELELSQKQLAEAMGITQPTLSAIENRGAEIKLSTLKRYVETMG
GKLRIDVELPTGKHVGFNI

Download         Length: 300 bp

>AT54178 NZ_CP011378:c1212871-1212572 [Moraxella bovoculi]
ATGGCAAATCTTAATGATATGCTTACCAAATTACAAAAAGAGCGTTTGGCTCGTGTGCAAAAAATGGCAGATGAGATGAT
TTTGGATTACAAGCTTCATCAGTTGCGTGAAGAGTTGGAGCTGTCGCAAAAACAGCTTGCCGAAGCCATGGGCATTACCC
AGCCTACCCTATCCGCCATTGAGAACCGCGGGGCAGAGATTAAGCTGTCCACACTAAAACGCTATGTGGAGACCATGGGC
GGAAAATTACGCATTGATGTGGAATTGCCGACAGGTAAGCACGTTGGGTTTAATATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References