Detailed information of TA system TA054176

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 1105119..1105694
• Replicon: chromosome
• Accession: NZ_CP011377
• Organism: Moraxella bovoculi strain 23343

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: AAX05_RS05415
• Protein ID: WP_046696629.1
• Coordinates: 1105440..1105694 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: AAX05_RS05410
• Protein ID: WP_046696628.1
• Coordinates: 1105119..1105418 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AAX05_RS05390	1101280..1101960	-	681	WP_046702108.1	hypothetical protein	-
AAX05_RS05395	1102000..1102626	-	627	WP_046696627.1	DUF262 domain-containing protein	-
AAX05_RS05400	1102729..1103349	-	621	WP_080947488.1	WYL domain-containing protein	-
AAX05_RS05405	1103511..1104950	+	1440	WP_155400009.1	ATP-binding protein	-
AAX05_RS05410	1105119..1105418	-	300	WP_046696628.1	helix-turn-helix transcriptional regulator	Antitoxin
AAX05_RS05415	1105440..1105694	-	255	WP_046696629.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AAX05_RS05420	1105974..1107365	-	1392	WP_046696630.1	class II fumarate hydratase	-
AAX05_RS05425	1107498..1108061	+	564	WP_046696631.1	5-formyltetrahydrofolate cyclo-ligase	-
AAX05_RS05430	1108066..1109133	-	1068	WP_046696632.1	4-hydroxythreonine-4-phosphate dehydrogenase PdxA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (5-77)

Antitoxin

• HigA2-like, helix-turn-helix domain (10-88)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9402.75 Da
• Isoelectric Point: 8.8755

>T54176 WP_046696629.1 NZ_CP011377:c1105694-1105440 [Moraxella bovoculi]
MTSGLQQYGHRLSLPYADTLYGSKFSNMKELRIQIGGGPDRAFYTFDSIRQAIVLCAGNKVGNEKQFYKQMIPLADEFIS
TAFG

Nucleotide

• Length: 255 bp

>T54176 NZ_CP011377:c1105694-1105440 [Moraxella bovoculi]
ATGACAAGTGGCTTACAACAATACGGACACCGATTATCCCTCCCTTATGCCGATACTTTATATGGCTCAAAATTTAGCAA
CATGAAAGAATTGCGTATCCAAATCGGGGGCGGCCCTGATCGTGCTTTTTATACGTTTGACTCCATACGTCAAGCGATTG
TGCTATGTGCAGGTAACAAAGTGGGCAATGAAAAGCAGTTTTATAAACAGATGATACCGCTTGCTGATGAGTTTATATCA
ACAGCATTTGGATAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11295.22 Da
• Isoelectric Point: 8.5370

>AT54176 WP_046696628.1 NZ_CP011377:c1105418-1105119 [Moraxella bovoculi]
MANLNDMLTKLQKERLARVQKMADEMILDYKLHQLREELELSQKQLAEAMGITQPTLSAIENRGAEIKLSTLKRYVETMG
GKLRIDVELPTGKHVGFNI

Nucleotide

• Length: 300 bp

>AT54176 NZ_CP011377:c1105418-1105119 [Moraxella bovoculi]
ATGGCAAATCTTAATGATATGCTTACCAAATTACAAAAAGAGCGTTTGGCTCGTGTGCAAAAAATGGCAGATGAGATGAT
TTTGGATTACAAGCTTCATCAGTTGCGTGAAGAGTTGGAGCTGTCGCAAAAACAGCTTGCCGAAGCCATGGGCATTACCC
AGCCTACCCTATCCGCCATTGAGAACCGCGGGGCAGAGATTAAGCTGTCCACACTAAAACGCTATGTGGAGACCATGGGC
GGAAAATTACGCATTGATGTGGAATTGCCGACAGGTAAGCACGTTGGGTTTAATATTTAA