Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 679563..680162 Replicon chromosome
Accession NZ_CP011377
Organism Moraxella bovoculi strain 23343

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag AAX05_RS03280 Protein ID WP_046696307.1
Coordinates 679563..679841 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag AAX05_RS03285 Protein ID WP_046696308.1
Coordinates 679857..680162 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AAX05_RS03270 676011..678862 - 2852 Protein_639 host specificity protein J -
AAX05_RS03275 678903..679478 - 576 WP_046696306.1 tail assembly protein -
AAX05_RS03280 679563..679841 + 279 WP_046696307.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AAX05_RS03285 679857..680162 + 306 WP_046696308.1 HigA family addiction module antidote protein Antitoxin
AAX05_RS03290 680134..680913 - 780 WP_046696309.1 C40 family peptidase -
AAX05_RS03295 680969..681355 - 387 WP_046696310.1 hypothetical protein -
AAX05_RS03300 681355..682128 - 774 WP_046696311.1 hypothetical protein -
AAX05_RS03305 682189..682902 - 714 WP_046696312.1 phage minor tail protein L -
AAX05_RS03310 682954..683352 - 399 WP_046696313.1 hypothetical protein -
AAX05_RS03315 683430..683759 - 330 WP_046696314.1 phage tail protein -
AAX05_RS03320 683804..684061 - 258 WP_046696315.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 671138..743495 72357


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10585.00 Da        Isoelectric Point: 5.0896

>T54175 WP_046696307.1 NZ_CP011377:679563-679841 [Moraxella bovoculi]
MIKGFKCKDTQSLFETGSSRVFSNFISVATRKLTMLDTATILADLRSPPANRLEKLTGDREGQYSIRINDQFRICFVWED
DGVYDVEIVDYH

Download         Length: 279 bp

>T54175 NZ_CP011377:679563-679841 [Moraxella bovoculi]
ATGATTAAAGGTTTTAAATGTAAAGACACCCAAAGCCTATTTGAGACAGGGTCAAGCCGTGTATTTTCTAATTTTATCTC
GGTTGCCACTCGTAAACTAACCATGCTTGATACCGCCACAATTCTTGCTGACTTACGCTCTCCACCTGCCAACCGCCTTG
AAAAACTCACAGGCGATAGAGAAGGTCAGTACAGCATTCGCATTAACGACCAATTTCGCATTTGCTTTGTGTGGGAAGAT
GATGGCGTGTACGATGTTGAGATTGTTGATTATCACTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11336.07 Da        Isoelectric Point: 7.0096

>AT54175 WP_046696308.1 NZ_CP011377:679857-680162 [Moraxella bovoculi]
MFKNGMRPVHAGEVLREEYLIPLGMSATALAKALGVTPARINDIVRQRRGITADTALRLARYFGGSPEFWLNLQMTYELR
LAQTELADSLEFISPYETAYA

Download         Length: 306 bp

>AT54175 NZ_CP011377:679857-680162 [Moraxella bovoculi]
ATGTTCAAAAATGGTATGAGACCCGTTCACGCAGGGGAGGTTTTGCGTGAAGAATATCTAATCCCACTGGGTATGTCCGC
CACTGCCTTAGCAAAGGCACTTGGTGTTACCCCCGCACGCATTAACGACATTGTGCGGCAGCGGCGTGGCATTACAGCCG
ATACCGCTTTGCGTTTGGCTCGTTATTTTGGTGGTAGTCCAGAGTTTTGGCTAAATTTGCAAATGACCTATGAACTTCGC
CTTGCCCAAACCGAACTGGCGGACAGCTTGGAGTTTATCAGTCCTTATGAAACCGCCTATGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References