Detailed information of TA system TA054172

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 1172632..1173207
• Replicon: chromosome
• Accession: NZ_CP011376
• Organism: Moraxella bovoculi strain 22581

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: AAX06_RS05540
• Protein ID: WP_046696629.1
• Coordinates: 1172632..1172886 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: AAX06_RS05545
• Protein ID: WP_046696628.1
• Coordinates: 1172908..1173207 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AAX06_RS05525	1169193..1170260	+	1068	WP_046696632.1	4-hydroxythreonine-4-phosphate dehydrogenase PdxA	-
AAX06_RS05530	1170265..1170828	-	564	WP_046696631.1	5-formyltetrahydrofolate cyclo-ligase	-
AAX06_RS05535	1170961..1172352	+	1392	WP_046696630.1	class II fumarate hydratase	-
AAX06_RS05540	1172632..1172886	+	255	WP_046696629.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AAX06_RS05545	1172908..1173207	+	300	WP_046696628.1	helix-turn-helix transcriptional regulator	Antitoxin
AAX06_RS05550	1173376..1174815	-	1440	WP_155400239.1	ATP-binding protein	-
AAX06_RS05555	1174977..1175597	+	621	WP_080946004.1	WYL domain-containing protein	-
AAX06_RS05560	1175700..1176326	+	627	WP_046696627.1	DUF262 domain-containing protein	-
AAX06_RS05565	1176366..1177046	+	681	WP_046702108.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (5-77)

Antitoxin

• HigA2-like, helix-turn-helix domain (10-88)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9402.75 Da
• Isoelectric Point: 8.8755

>T54172 WP_046696629.1 NZ_CP011376:1172632-1172886 [Moraxella bovoculi]
MTSGLQQYGHRLSLPYADTLYGSKFSNMKELRIQIGGGPDRAFYTFDSIRQAIVLCAGNKVGNEKQFYKQMIPLADEFIS
TAFG

Nucleotide

• Length: 255 bp

>T54172 NZ_CP011376:1172632-1172886 [Moraxella bovoculi]
ATGACAAGTGGCTTACAACAATACGGACACCGATTATCCCTCCCTTATGCCGATACTTTATATGGCTCAAAATTTAGCAA
CATGAAAGAATTGCGTATCCAAATCGGGGGCGGCCCTGATCGTGCTTTTTATACGTTTGACTCCATACGTCAAGCGATTG
TGCTATGTGCAGGTAACAAAGTGGGCAATGAAAAGCAGTTTTATAAACAGATGATACCGCTTGCTGATGAGTTTATATCA
ACAGCATTTGGATAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11295.22 Da
• Isoelectric Point: 8.5370

>AT54172 WP_046696628.1 NZ_CP011376:1172908-1173207 [Moraxella bovoculi]
MANLNDMLTKLQKERLARVQKMADEMILDYKLHQLREELELSQKQLAEAMGITQPTLSAIENRGAEIKLSTLKRYVETMG
GKLRIDVELPTGKHVGFNI

Nucleotide

• Length: 300 bp

>AT54172 NZ_CP011376:1172908-1173207 [Moraxella bovoculi]
ATGGCAAATCTTAATGATATGCTTACCAAATTACAAAAAGAGCGTTTGGCTCGTGTGCAAAAAATGGCAGATGAGATGAT
TTTGGATTACAAGCTTCATCAGTTGCGTGAAGAGTTGGAGCTGTCGCAAAAACAGCTTGCCGAAGCCATGGGCATTACCC
AGCCTACCCTATCCGCCATTGAGAACCGCGGGGCAGAGATTAAGCTGTCCACACTAAAACGCTATGTGGAGACCATGGGC
GGAAAATTACGCATTGATGTGGAATTGCCGACAGGTAAGCACGTTGGGTTTAATATTTAA