Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 883008..883531 Replicon chromosome
Accession NZ_CP011366
Organism Salinicoccus halodurans strain H3B36 isolate soil

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0F7HKB4
Locus tag AAT16_RS04380 Protein ID WP_046789707.1
Coordinates 883265..883531 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0F7HJG8
Locus tag AAT16_RS04375 Protein ID WP_046789706.1
Coordinates 883008..883265 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AAT16_RS04335 878162..878977 - 816 WP_046789698.1 YsnF/AvaK domain-containing protein -
AAT16_RS04340 879175..879588 + 414 WP_046789699.1 PLDc N-terminal domain-containing protein -
AAT16_RS04345 879833..880405 + 573 WP_046789700.1 YdcF family protein -
AAT16_RS04350 880524..881132 + 609 WP_046789701.1 hypothetical protein -
AAT16_RS04355 881213..881479 - 267 Protein_868 copper amine oxidase -
AAT16_RS14295 881795..881962 + 168 WP_082103650.1 type II toxin-antitoxin system RelE/ParE family toxin -
AAT16_RS04365 882045..882287 + 243 WP_046789704.1 helix-turn-helix transcriptional regulator -
AAT16_RS04370 882374..882925 + 552 WP_046789705.1 GNAT family N-acetyltransferase -
AAT16_RS04375 883008..883265 + 258 WP_046789706.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AAT16_RS04380 883265..883531 + 267 WP_046789707.1 Txe/YoeB family addiction module toxin Toxin
AAT16_RS04385 883697..884314 + 618 WP_046791444.1 copper resistance protein CopC -
AAT16_RS04390 884327..885445 + 1119 WP_046789708.1 CopD family protein -
AAT16_RS04395 885726..887135 + 1410 WP_046789709.1 sodium:solute symporter family protein -
AAT16_RS04400 887135..888271 + 1137 WP_046791445.1 Xaa-Pro peptidase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(24-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-67)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10590.97 Da        Isoelectric Point: 10.0535

>T54165 WP_046789707.1 NZ_CP011366:883265-883531 [Salinicoccus halodurans]
MSNYRIVIKNSAKSDLKKIKHSNLKSQFEDVIDVLKENPYYPNQSFEKLQPKNQGRYSRRINQQHRVVYKVDDSLKQVEI
YSAWSHYE

Download         Length: 267 bp

>T54165 NZ_CP011366:883265-883531 [Salinicoccus halodurans]
ATGTCGAATTATCGTATAGTGATAAAAAATTCGGCTAAAAGCGACTTGAAGAAAATAAAGCATTCTAACTTGAAGAGCCA
GTTTGAAGATGTAATTGATGTTTTGAAAGAAAATCCATATTATCCAAACCAATCGTTTGAAAAACTGCAACCTAAAAATC
AAGGGCGGTATTCAAGAAGAATTAATCAGCAGCATAGAGTAGTTTATAAAGTCGATGATTCTTTAAAACAAGTTGAAATA
TATTCGGCTTGGTCTCACTATGAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9862.86 Da        Isoelectric Point: 4.0440

>AT54165 WP_046789706.1 NZ_CP011366:883008-883265 [Salinicoccus halodurans]
MDIMSPTDARKDFYSVLKRVNEDHQPVIINGSKENSNAVIISQEDWQSIQETLFLEQTGVMDKVRKRETDESGFTDIDDL
DWDNI

Download         Length: 258 bp

>AT54165 NZ_CP011366:883008-883265 [Salinicoccus halodurans]
ATGGATATTATGTCCCCAACAGATGCAAGAAAAGATTTTTACAGTGTACTTAAACGCGTTAATGAAGATCACCAACCGGT
CATTATTAATGGGAGCAAGGAAAACAGTAATGCTGTAATCATCAGTCAAGAAGATTGGCAAAGTATACAGGAAACTCTGT
TTCTGGAACAAACCGGCGTAATGGACAAAGTCAGGAAAAGAGAAACAGACGAGAGTGGGTTTACCGATATTGATGATTTG
GATTGGGATAATATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F7HKB4

Antitoxin

Source ID Structure
AlphaFold DB A0A0F7HJG8

References