Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1980756..1981269 Replicon chromosome
Accession NZ_CP011329
Organism Streptococcus agalactiae strain H002

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DX49
Locus tag SAH002_RS09900 Protein ID WP_000481712.1
Coordinates 1980756..1981010 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q8DX48
Locus tag SAH002_RS09905 Protein ID WP_000387490.1
Coordinates 1981003..1981269 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAH002_RS09880 1976528..1979029 - 2502 WP_000239405.1 ATP-binding protein -
SAH002_RS09885 1979050..1979460 - 411 WP_000390748.1 conjugal transfer protein -
SAH002_RS09890 1979464..1979730 - 267 WP_001055036.1 hypothetical protein -
SAH002_RS09895 1979750..1980703 - 954 WP_000565542.1 conjugal transfer protein -
SAH002_RS09900 1980756..1981010 - 255 WP_000481712.1 Txe/YoeB family addiction module toxin Toxin
SAH002_RS09905 1981003..1981269 - 267 WP_000387490.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
SAH002_RS09910 1981414..1981887 - 474 WP_000560386.1 hypothetical protein -
SAH002_RS09915 1981895..1982377 - 483 WP_000383282.1 antirestriction protein ArdA -
SAH002_RS09920 1982429..1982701 - 273 WP_000072642.1 hypothetical protein -
SAH002_RS09925 1982833..1983186 - 354 WP_000571928.1 helix-turn-helix domain-containing protein -
SAH002_RS09930 1983179..1983394 - 216 WP_001897988.1 helix-turn-helix domain-containing protein -
SAH002_RS09935 1983378..1983755 - 378 WP_000287184.1 hypothetical protein -
SAH002_RS09940 1983771..1985003 - 1233 WP_000338840.1 replication initiation factor domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - cfa/cfb 1969011..2029642 60631


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10445.87 Da        Isoelectric Point: 6.7282

>T54003 WP_000481712.1 NZ_CP011329:c1981010-1980756 [Streptococcus agalactiae]
MFNFTEEAWKDYVSWQQEDKKILKRINRLIEDIKRDPFEGIGKPEPLKYHYSGAWSRRITEEHRLIYMIEDGEIYFLSFR
DHYK

Download         Length: 255 bp

>T54003 NZ_CP011329:c1981010-1980756 [Streptococcus agalactiae]
ATGTTTAATTTTACTGAAGAAGCATGGAAAGATTATGTTTCTTGGCAACAGGAAGATAAAAAAATCTTGAAACGAATTAA
TCGTTTGATAGAAGATATTAAAAGAGACCCATTTGAAGGCATTGGAAAACCAGAACCTTTAAAATACCATTATTCAGGGG
CTTGGTCTCGAAGAATTACAGAAGAACATAGGTTGATTTATATGATAGAAGATGGAGAAATCTATTTTTTATCTTTTAGA
GATCATTATAAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10316.70 Da        Isoelectric Point: 4.6742

>AT54003 WP_000387490.1 NZ_CP011329:c1981269-1981003 [Streptococcus agalactiae]
MEAIVYSHFRNNLKDYMKKVNDEFEPLIVVNKNPDENIVVLSQDSWESLQETIRLMENDYLSHKVINGISQVKEKQVTKH
GLIEVEDV

Download         Length: 267 bp

>AT54003 NZ_CP011329:c1981269-1981003 [Streptococcus agalactiae]
ATGGAGGCTATTGTTTATTCACATTTTAGAAATAATTTAAAAGATTATATGAAGAAGGTCAATGATGAATTTGAGCCTTT
GATTGTAGTTAATAAAAATCCTGATGAAAATATAGTGGTTTTATCTCAAGATAGCTGGGAAAGTTTACAAGAAACGATTC
GTTTGATGGAAAATGATTATCTATCACATAAGGTTATTAATGGTATATCACAAGTTAAAGAGAAGCAAGTCACTAAACAT
GGTTTAATTGAGGTAGAAGATGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829IC12

Antitoxin

Source ID Structure
AlphaFold DB A0A829I9V6

References