53983

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2080922..2081424 Replicon chromosome
Accession NZ_CP011324
Organism Escherichia coli strain SQ2203

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag CS35_RS10495 Protein ID WP_000767829.1
Coordinates 2080922..2081176 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag CS35_RS10500 Protein ID WP_001259255.1
Coordinates 2081173..2081424 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CS35_RS10470 2075937..2076164 - 228 WP_000234896.1 sulfurtransferase TusA -
CS35_RS10475 2076178..2077236 - 1059 WP_000492339.1 transport protein YeeE -
CS35_RS10480 2077415..2078773 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
CS35_RS25490 2078763..2078825 - 63 WP_010723108.1 membrane protein YoeI -
CS35_RS10485 2079040..2079969 - 930 WP_000803351.1 LysR family transcriptional regulator -
CS35_RS10490 2080015..2080839 - 825 WP_000754737.1 SDR family oxidoreductase -
CS35_RS10495 2080922..2081176 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
CS35_RS10500 2081173..2081424 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
CS35_RS23835 2081707..2081757 + 51 WP_001364200.1 his operon leader peptide -
CS35_RS10505 2081903..2082802 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
CS35_RS10510 2082808..2084112 + 1305 WP_000009594.1 histidinol dehydrogenase -
CS35_RS10515 2084109..2085179 + 1071 WP_000108941.1 histidinol-phosphate transaminase -
CS35_RS10520 2085179..2086246 + 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T53983 WP_000767829.1 NZ_CP011324:c2081176-2080922 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T53983 NZ_CP011324:c2081176-2080922 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT53983 WP_001259255.1 NZ_CP011324:c2081424-2081173 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT53983 NZ_CP011324:c2081424-2081173 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References