53897

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2080922..2081424 Replicon chromosome
Accession NZ_CP011321
Organism Escherichia coli strain SQ88

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag SG49_RS10495 Protein ID WP_000767829.1
Coordinates 2080922..2081176 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag SG49_RS10500 Protein ID WP_001259255.1
Coordinates 2081173..2081424 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SG49_RS10470 2075937..2076164 - 228 WP_000234896.1 sulfurtransferase TusA -
SG49_RS10475 2076178..2077236 - 1059 WP_000492339.1 transport protein YeeE -
SG49_RS10480 2077415..2078773 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
SG49_RS25510 2078763..2078825 - 63 WP_010723108.1 membrane protein YoeI -
SG49_RS10485 2079040..2079969 - 930 WP_000803351.1 LysR family transcriptional regulator -
SG49_RS10490 2080015..2080839 - 825 WP_000754737.1 SDR family oxidoreductase -
SG49_RS10495 2080922..2081176 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
SG49_RS10500 2081173..2081424 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
SG49_RS23865 2081707..2081757 + 51 WP_001364200.1 his operon leader peptide -
SG49_RS10505 2081903..2082802 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
SG49_RS10510 2082808..2084112 + 1305 WP_000009594.1 histidinol dehydrogenase -
SG49_RS10515 2084109..2085179 + 1071 WP_000108941.1 histidinol-phosphate transaminase -
SG49_RS10520 2085179..2086246 + 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T53897 WP_000767829.1 NZ_CP011321:c2081176-2080922 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T53897 NZ_CP011321:c2081176-2080922 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT53897 WP_001259255.1 NZ_CP011321:c2081424-2081173 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT53897 NZ_CP011321:c2081424-2081173 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References