Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 3291877..3292396 Replicon chromosome
Accession NZ_CP011304
Organism Microcystis aeruginosa NIES-2549

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0F6U6Y9
Locus tag myaer_RS16205 Protein ID WP_046662850.1
Coordinates 3291877..3292143 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID I4GT15
Locus tag myaer_RS16210 Protein ID WP_002783395.1
Coordinates 3292136..3292396 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
myaer_RS16150 3286979..3287242 - 264 WP_046663814.1 HigA family addiction module antidote protein -
myaer_RS16155 3287472..3287708 + 237 WP_008202209.1 hypothetical protein -
myaer_RS16160 3287708..3288160 + 453 WP_002750618.1 PIN domain-containing protein -
myaer_RS16165 3288321..3288572 - 252 WP_004162266.1 hypothetical protein -
myaer_RS16170 3288565..3288810 - 246 WP_002734321.1 hypothetical protein -
myaer_RS16175 3289153..3289869 + 717 WP_046662848.1 PEP-CTERM sorting domain-containing protein -
myaer_RS16180 3290033..3290287 + 255 WP_002734916.1 hypothetical protein -
myaer_RS16185 3290288..3290623 + 336 WP_002768260.1 type II toxin-antitoxin system PemK/MazF family toxin -
myaer_RS16195 3290978..3291271 + 294 WP_002783391.1 nucleotidyltransferase family protein -
myaer_RS16200 3291268..3291612 + 345 WP_046662849.1 DUF86 domain-containing protein -
myaer_RS16205 3291877..3292143 - 267 WP_046662850.1 Txe/YoeB family addiction module toxin Toxin
myaer_RS16210 3292136..3292396 - 261 WP_002783395.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
myaer_RS16220 3292763..3293800 - 1038 WP_046662851.1 fatty acid desaturase -
myaer_RS16225 3294107..3295270 - 1164 WP_046662852.1 pyridoxal phosphate-dependent aminotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10473.06 Da        Isoelectric Point: 9.8354

>T53809 WP_046662850.1 NZ_CP011304:c3292143-3291877 [Microcystis aeruginosa NIES-2549]
MDNWQLFFTKQAKKDAEKLARTGLAKQANELLNILKSNPYQSYPVYEKLSGDLASYYSRRINIQHRLVDQVIPEEKVVKI
IRMWTHYE

Download         Length: 267 bp

>T53809 NZ_CP011304:c3292143-3291877 [Microcystis aeruginosa NIES-2549]
ATGGATAATTGGCAGTTGTTTTTTACCAAACAAGCGAAAAAAGATGCTGAAAAGCTGGCTCGTACTGGGTTGGCAAAACA
AGCTAACGAGTTATTAAATATTCTTAAGTCAAATCCCTATCAATCTTATCCTGTTTATGAGAAACTCAGTGGTGATTTAG
CGAGCTATTATTCTAGACGTATTAATATTCAGCATCGTTTGGTTGATCAGGTTATTCCAGAAGAGAAGGTTGTCAAAATT
ATACGGATGTGGACTCATTATGAATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9446.59 Da        Isoelectric Point: 3.8305

>AT53809 WP_002783395.1 NZ_CP011304:c3292396-3292136 [Microcystis aeruginosa NIES-2549]
MKIVTVTEAKEQIDELVNDTNDNHQPILLSGTKKNAILIAEEDWNSIQETLYLYSIPGMVDSIIEGGNTSIEDCLDEAGI
RAILNG

Download         Length: 261 bp

>AT53809 NZ_CP011304:c3292396-3292136 [Microcystis aeruginosa NIES-2549]
ATGAAAATTGTTACTGTTACTGAGGCCAAAGAACAAATTGATGAATTAGTGAATGATACCAATGATAATCATCAACCGAT
TTTGTTATCTGGTACGAAAAAGAATGCTATTTTAATTGCTGAGGAAGATTGGAACTCTATTCAAGAAACGCTTTATTTGT
ATTCTATTCCTGGTATGGTAGATTCAATTATTGAAGGTGGCAACACTTCTATTGAAGATTGTCTGGATGAGGCGGGTATC
AGAGCAATTTTAAATGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F6U6Y9

Antitoxin

Source ID Structure
AlphaFold DB I4GT15

References