Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 379485..380112 Replicon chromosome
Accession NZ_CP011303
Organism Serratia liquefaciens strain HUMV-21

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag XJ20_RS01830 Protein ID WP_041415718.1
Coordinates 379822..380112 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag XJ20_RS01825 Protein ID WP_046372572.1
Coordinates 379485..379808 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XJ20_RS01805 375930..376904 - 975 WP_200898907.1 TerC family protein -
XJ20_RS01810 377166..377897 - 732 WP_046372570.1 glutamine amidotransferase -
XJ20_RS01815 377899..378879 - 981 WP_046372571.1 Gfo/Idh/MocA family oxidoreductase -
XJ20_RS01820 378980..379492 - 513 WP_020831788.1 M48 family metallopeptidase -
XJ20_RS01825 379485..379808 - 324 WP_046372572.1 HigA family addiction module antidote protein Antitoxin
XJ20_RS01830 379822..380112 - 291 WP_041415718.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
XJ20_RS01835 380343..381482 + 1140 WP_020831785.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
XJ20_RS01840 381527..383548 - 2022 WP_046372573.1 NADPH-dependent 2,4-dienoyl-CoA reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(24-71)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11493.02 Da        Isoelectric Point: 9.4772

>T53790 WP_041415718.1 NZ_CP011303:c380112-379822 [Serratia liquefaciens]
MISSFRDGYLAQFYREGRRDRLIPSTIERQLARKLDMLAAAQKECDLHNPTGNYYKRLSGPFQGWSSMRVNLQWRLMFQW
RHDAAEQIYLDPHQDT

Download         Length: 291 bp

>T53790 NZ_CP011303:c380112-379822 [Serratia liquefaciens]
ATGATTTCATCGTTCCGAGACGGATACCTGGCGCAATTCTATAGGGAGGGTCGGCGCGATCGTTTGATCCCCTCGACCAT
TGAGCGCCAACTGGCCAGAAAACTCGATATGCTGGCTGCTGCGCAAAAAGAATGTGATTTACATAACCCGACCGGTAATT
ATTACAAACGTCTGTCCGGCCCCTTTCAAGGCTGGTCCAGCATGCGGGTGAATCTTCAATGGCGATTAATGTTTCAATGG
CGCCACGATGCGGCTGAGCAGATTTATTTGGATCCGCACCAAGATACCTAG

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12163.83 Da        Isoelectric Point: 6.8717

>AT53790 WP_046372572.1 NZ_CP011303:c379808-379485 [Serratia liquefaciens]
MLETTSRKPTTVGEVLQEEYLTPLGIGQEDLAKVLGVTRATVNRLCNGHRRLSVAEANLFADLFETTADFWLNLQAAHDR
WEARQANVHRERLRPIMEILGRNITHA

Download         Length: 324 bp

>AT53790 NZ_CP011303:c379808-379485 [Serratia liquefaciens]
ATGTTAGAGACTACAAGCCGGAAACCCACTACGGTGGGGGAAGTGCTGCAAGAGGAGTATTTAACACCGCTGGGCATTGG
GCAGGAGGATCTTGCAAAGGTCTTGGGTGTCACCCGTGCCACGGTAAATCGCTTGTGCAATGGACATCGTCGTCTAAGCG
TTGCGGAAGCGAACTTGTTCGCCGATCTGTTCGAAACCACCGCCGATTTCTGGCTAAACCTGCAAGCGGCCCACGACCGT
TGGGAAGCCCGACAGGCCAATGTACACCGCGAGCGTCTGCGTCCGATTATGGAAATATTGGGGCGTAATATTACTCATGC
GTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References