Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1843984..1844546 Replicon chromosome
Accession NZ_CP011254
Organism Serratia fonticola strain DSM 4576

Toxin (Protein)


Gene name higB Uniprot ID A0A3G2FJW6
Locus tag WN53_RS08155 Protein ID WP_024483282.1
Coordinates 1843984..1844262 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag WN53_RS08160 Protein ID WP_024483281.1
Coordinates 1844262..1844546 (+) Length 95 a.a.

Genomic Context

WN53_RS08140WN53_RS08145WN53_RS08150WN53_RS08155WN53_RS08160WN53_RS08165WN53_RS08170WN53_RS08175
Location: 1839812..1840720 (909 bp)
Type: Others
Protein ID: WP_024483285.1
Location: 1840729..1842798 (2070 bp)
Type: Others
Protein ID: WP_024483284.1
Location: 1842996..1843715 (720 bp)
Type: Others
Protein ID: WP_024483283.1
Location: 1843984..1844262 (279 bp)
Type: Toxin
Protein ID: WP_024483282.1
Location: 1844262..1844546 (285 bp)
Type: Antitoxin
Protein ID: WP_024483281.1
Location: 1845113..1847029 (1917 bp)
Type: Others
Protein ID: WP_024483280.1
Location: 1847092..1848240 (1149 bp)
Type: Others
Protein ID: WP_024483279.1
Location: 1848390..1848962 (573 bp)
Type: Others
Protein ID: WP_161629419.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
WN53_RS081401839812..1840720+909WP_024483285.1glycine--tRNA ligase subunit alpha-
WN53_RS081451840729..1842798+2070WP_024483284.1glycine--tRNA ligase subunit beta-
WN53_RS081501842996..1843715+720WP_024483283.1DUF3053 domain-containing protein-
WN53_RS081551843984..1844262+279WP_024483282.1type II toxin-antitoxin system RelE/ParE family toxinToxin
WN53_RS081601844262..1844546+285WP_024483281.1HigA family addiction module antidote proteinAntitoxin
WN53_RS081651845113..1847029+1917WP_024483280.1PTS mannitol transporter subunit IICBA-
WN53_RS081701847092..1848240+1149WP_024483279.1mannitol-1-phosphate 5-dehydrogenase-
WN53_RS081751848390..1848962+573WP_161629419.1MltR family transcriptional regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-81)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10486.86 Da        Isoelectric Point: 9.4604

>T53719 WP_024483282.1 NZ_CP011254:1843984-1844262 [Serratia fonticola]
MIKSFKHKGLRQFFEKGSTAGINTQQIGKIRLRLGVIDAAKDISDINRPGYQLHPLSGDRAGQWSITVTGNWRITFEFID
GDAYIVNYEDYH

Download         Length: 279 bp

>T53719 NZ_CP011254:1843984-1844262 [Serratia fonticola]
ATGATTAAGAGTTTTAAGCACAAGGGATTGCGACAGTTTTTTGAGAAAGGCTCTACGGCTGGCATCAATACTCAACAGAT
CGGTAAAATTCGTCTGAGGCTTGGTGTAATTGATGCAGCAAAGGACATCAGTGATATCAACCGCCCTGGCTATCAACTTC
ACCCATTGTCGGGTGACCGTGCCGGGCAGTGGTCAATAACCGTAACAGGCAACTGGCGCATCACGTTTGAATTTATCGAC
GGTGATGCCTATATCGTCAACTATGAGGATTATCACTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10107.83 Da        Isoelectric Point: 8.7051

>AT53719 WP_024483281.1 NZ_CP011254:1844262-1844546 [Serratia fonticola]
MAMHNPPHPGEIIAETLEELGVGIRVFARALMVAPSTAQRLVAGNAAVSPEMAVKLSIVLGSSPEFWLNLQDNYSLWIAK
KAVNTSQLKRLVAA

Download         Length: 285 bp

>AT53719 NZ_CP011254:1844262-1844546 [Serratia fonticola]
ATGGCTATGCATAACCCCCCGCATCCGGGCGAGATCATCGCTGAAACGCTGGAAGAACTGGGTGTTGGTATCCGCGTATT
TGCCAGGGCGTTGATGGTGGCACCCTCCACCGCACAGCGCTTGGTCGCAGGGAATGCGGCTGTTAGCCCTGAGATGGCGG
TGAAGTTGTCCATAGTGCTGGGCAGTTCCCCTGAATTCTGGCTAAACCTGCAGGATAATTACAGCCTGTGGATCGCCAAA
AAAGCAGTCAATACTTCGCAGCTAAAGCGTTTGGTTGCCGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A3G2FJW6

Antitoxin

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Source
ID
Structure
No matching records found

References