Detailed information of TA system TA053689

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 2473930..2474585
• Replicon: chromosome
• Accession: NZ_CP011239
• Organism: Bordetella pertussis strain H915

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: XA12_RS11955
• Protein ID: WP_047122780.1
• Coordinates: 2474334..2474585 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: XA12_RS11950
• Protein ID: WP_003809516.1
• Coordinates: 2473930..2474331 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XA12_RS11920	2469113..2470135	-	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-
XA12_RS11925	2470272..2471309	-	1038	WP_023853543.1	threonylcarbamoyl-AMP synthase	-
XA12_RS11930	2471329..2472519	-	1191	WP_010930406.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
XA12_RS11935	2472522..2473037	-	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
XA12_RS11940	2473187..2473666	-	480	WP_010930405.1	disulfide bond formation protein B	-
XA12_RS11945	2473674..2473910	-	237	WP_010930404.1	membrane protein	-
XA12_RS11950	2473930..2474331	-	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
XA12_RS11955	2474334..2474585	-	252	WP_047122780.1	type II toxin-antitoxin system MqsR family toxin	Toxin
XA12_RS11960	2474640..2475521	-	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
XA12_RS11965	2475746..2476192	+	447	WP_003819827.1	GFA family protein	-
XA12_RS11970	2476277..2477341	-	1065	WP_003809510.1	fructose-bisphosphate aldolase class II	-
XA12_RS11975	2477478..2478059	-	582	WP_019247931.1	molybdenum cofactor biosysynthesis protein	-
XA12_RS11980	2478294..2479424	+	1131	WP_010930401.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (10-82)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 8952.52 Da
• Isoelectric Point: 9.7242

>T53689 WP_047122780.1 NZ_CP011239:c2474585-2474334 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Nucleotide

• Length: 252 bp

>T53689 NZ_CP011239:c2474585-2474334 [Bordetella pertussis]
ATTGGAGGCGCGGCGACAAAAAAGCCGGGACAAAAGCGTCGCGCCGGGGCGGCGGCGCTGGGGCTGGATTTCAGCGCCAT
GGTCGAAATCGTGCTTGCATTGACACCGCGGGATTTCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGG
ACGTCTATTGCCCGGTGACAGCGATGGGCGCCGTCTACCTGAAGCTGACGGTCCTCGACGGCGTGCCGATCGTGTCGTTC
AAGGAGTTGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT53689 WP_003809516.1 NZ_CP011239:c2474331-2473930 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT53689 NZ_CP011239:c2474331-2473930 [Bordetella pertussis]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACGATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCTGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGCTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Structures

Antitoxin

• AlphaFold DB: A0A0H3LKS6