Detailed information of TA system TA053616

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1582557..1583212
• Replicon: chromosome
• Accession: NZ_CP011177
• Organism: Bordetella pertussis strain F034

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: WU11_RS07720
• Protein ID: WP_047122780.1
• Coordinates: 1582557..1582808 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: WU11_RS07725
• Protein ID: WP_003809516.1
• Coordinates: 1582811..1583212 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WU11_RS07695	1577718..1578848	-	1131	WP_010930401.1	helix-turn-helix transcriptional regulator	-
WU11_RS07700	1579083..1579664	+	582	WP_019247931.1	molybdenum cofactor biosysynthesis protein	-
WU11_RS07705	1579801..1580865	+	1065	WP_003809510.1	fructose-bisphosphate aldolase class II	-
WU11_RS07710	1580950..1581396	-	447	WP_003819827.1	GFA family protein	-
WU11_RS07715	1581621..1582502	+	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
WU11_RS07720	1582557..1582808	+	252	WP_047122780.1	type II toxin-antitoxin system MqsR family toxin	Toxin
WU11_RS07725	1582811..1583212	+	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
WU11_RS07730	1583232..1583468	+	237	WP_010930404.1	membrane protein	-
WU11_RS07735	1583476..1583955	+	480	WP_010930405.1	disulfide bond formation protein B	-
WU11_RS07740	1584105..1584620	+	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
WU11_RS07745	1584623..1585813	+	1191	WP_010930406.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
WU11_RS07750	1585833..1586870	+	1038	WP_023853543.1	threonylcarbamoyl-AMP synthase	-
WU11_RS07755	1587007..1588029	+	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (10-82)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 8952.52 Da
• Isoelectric Point: 9.7242

>T53616 WP_047122780.1 NZ_CP011177:1582557-1582808 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Nucleotide

• Length: 252 bp

>T53616 NZ_CP011177:1582557-1582808 [Bordetella pertussis]
ATTGGAGGCGCGGCGACAAAAAAGCCGGGACAAAAGCGTCGCGCCGGGGCGGCGGCGCTGGGGCTGGATTTCAGCGCCAT
GGTCGAAATCGTGCTTGCATTGACACCGCGGGATTTCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGG
ACGTCTATTGCCCGGTGACAGCGATGGGCGCCGTCTACCTGAAGCTGACGGTCCTCGACGGCGTGCCGATCGTGTCGTTC
AAGGAGTTGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT53616 WP_003809516.1 NZ_CP011177:1582811-1583212 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT53616 NZ_CP011177:1582811-1583212 [Bordetella pertussis]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACGATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCTGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGCTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Structures

Antitoxin

• AlphaFold DB: A0A0H3LKS6