Detailed information of TA system TA053602

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 2527814..2528469
• Replicon: chromosome
• Accession: NZ_CP011170
• Organism: Bordetella pertussis strain D879

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: WU04_RS12215
• Protein ID: WP_047122780.1
• Coordinates: 2528218..2528469 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: WU04_RS12210
• Protein ID: WP_003809516.1
• Coordinates: 2527814..2528215 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WU04_RS12180	2522997..2524019	-	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-
WU04_RS12185	2524156..2525193	-	1038	WP_023853543.1	threonylcarbamoyl-AMP synthase	-
WU04_RS12190	2525213..2526403	-	1191	WP_010930406.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
WU04_RS12195	2526406..2526921	-	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
WU04_RS12200	2527071..2527550	-	480	WP_010930405.1	disulfide bond formation protein B	-
WU04_RS12205	2527558..2527794	-	237	WP_010930404.1	membrane protein	-
WU04_RS12210	2527814..2528215	-	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
WU04_RS12215	2528218..2528469	-	252	WP_047122780.1	type II toxin-antitoxin system MqsR family toxin	Toxin
WU04_RS12220	2528524..2529405	-	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
WU04_RS12225	2529630..2530076	+	447	WP_003819827.1	GFA family protein	-
WU04_RS12230	2530161..2531225	-	1065	WP_003809510.1	fructose-bisphosphate aldolase class II	-
WU04_RS12235	2531362..2531943	-	582	WP_019247931.1	molybdenum cofactor biosysynthesis protein	-
WU04_RS12240	2532178..2533308	+	1131	WP_010930401.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (10-82)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 8952.52 Da
• Isoelectric Point: 9.7242

>T53602 WP_047122780.1 NZ_CP011170:c2528469-2528218 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Nucleotide

• Length: 252 bp

>T53602 NZ_CP011170:c2528469-2528218 [Bordetella pertussis]
ATTGGAGGCGCGGCGACAAAAAAGCCGGGACAAAAGCGTCGCGCCGGGGCGGCGGCGCTGGGGCTGGATTTCAGCGCCAT
GGTCGAAATCGTGCTTGCATTGACACCGCGGGATTTCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGG
ACGTCTATTGCCCGGTGACAGCGATGGGCGCCGTCTACCTGAAGCTGACGGTCCTCGACGGCGTGCCGATCGTGTCGTTC
AAGGAGTTGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT53602 WP_003809516.1 NZ_CP011170:c2528215-2527814 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT53602 NZ_CP011170:c2528215-2527814 [Bordetella pertussis]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACGATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCTGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGCTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Structures

Antitoxin

• AlphaFold DB: A0A0H3LKS6