Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2536516..2536700 Replicon chromosome
Accession NZ_CP011147
Organism Staphylococcus aureus strain FCFHV36

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag FCFHV36_RS15950 Protein ID WP_000482652.1
Coordinates 2536593..2536700 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2536516..2536576 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FCFHV36_RS15935 2531971..2532138 - 168 Protein_2458 hypothetical protein -
FCFHV36_RS12935 2532369..2534102 - 1734 WP_000486487.1 ABC transporter ATP-binding protein/permease -
FCFHV36_RS12940 2534127..2535890 - 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
- 2536516..2536576 + 61 - - Antitoxin
FCFHV36_RS15950 2536593..2536700 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
FCFHV36_RS12955 2536834..2537220 - 387 WP_000779360.1 flippase GtxA -
FCFHV36_RS12960 2537488..2538630 + 1143 WP_001176863.1 glycerate kinase -
FCFHV36_RS12965 2538690..2539349 + 660 WP_000831298.1 membrane protein -
FCFHV36_RS12970 2539531..2540742 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
FCFHV36_RS12975 2540865..2541338 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T53575 WP_000482652.1 NZ_CP011147:c2536700-2536593 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T53575 NZ_CP011147:c2536700-2536593 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT53575 NZ_CP011147:2536516-2536576 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References