Detailed information of TA system TA053568

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 2080247..2080554
• Replicon: chromosome
• Accession: NZ_CP011147
• Organism: Staphylococcus aureus strain FCFHV36

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: FCFHV36_RS15645
• Protein ID: WP_011447039.1
• Coordinates: 2080378..2080554 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2080247..2080386 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FCFHV36_RS15620	2075586..2075846	+	261	WP_001791826.1	hypothetical protein	-
FCFHV36_RS10440	2075899..2076249	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
FCFHV36_RS10445	2076934..2077383	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
FCFHV36_RS16300	2077478..2077813	-	336	Protein_1985	SH3 domain-containing protein	-
FCFHV36_RS10455	2078463..2078954	-	492	WP_000919350.1	staphylokinase	-
FCFHV36_RS10460	2079145..2079900	-	756	WP_000861038.1	CHAP domain-containing protein	-
FCFHV36_RS10465	2079912..2080166	-	255	WP_000611512.1	phage holin	-
FCFHV36_RS15640	2080218..2080325	+	108	WP_001791821.1	hypothetical protein	-
-	2080247..2080386	+	140	NuclAT_0	-	Antitoxin
-	2080247..2080386	+	140	NuclAT_0	-	Antitoxin
-	2080247..2080386	+	140	NuclAT_0	-	Antitoxin
-	2080247..2080386	+	140	NuclAT_0	-	Antitoxin
FCFHV36_RS15645	2080378..2080554	-	177	WP_011447039.1	putative holin-like toxin	Toxin
FCFHV36_RS10480	2080704..2081000	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
FCFHV36_RS10485	2081058..2081345	-	288	WP_001040261.1	hypothetical protein	-
FCFHV36_RS15650	2081392..2081544	-	153	WP_001153681.1	hypothetical protein	-
FCFHV36_RS10495	2081534..2085319	-	3786	WP_000582154.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2075899..2126392	50493

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T53568 WP_011447039.1 NZ_CP011147:c2080554-2080378 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T53568 NZ_CP011147:c2080554-2080378 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT53568 NZ_CP011147:2080247-2080386 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin