Detailed information of TA system TA053565

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2004551..2005130
• Replicon: chromosome
• Accession: NZ_CP011147
• Organism: Staphylococcus aureus strain FCFHV36

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: FCFHV36_RS10030
• Protein ID: WP_001025401.1
• Coordinates: 2004885..2005130 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2004551..2004916 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FCFHV36_RS09990	2001294..2001851	-	558	WP_000645048.1	DUF2815 family protein	-
FCFHV36_RS09995	2001877..2003043	-	1167	WP_000762530.1	DUF2800 domain-containing protein	-
FCFHV36_RS10000	2003040..2003402	-	363	WP_000985972.1	hypothetical protein	-
FCFHV36_RS10005	2003417..2003740	-	324	WP_000174998.1	hypothetical protein	-
FCFHV36_RS15545	2003819..2003980	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
FCFHV36_RS10015	2003993..2004256	-	264	WP_001124157.1	helix-turn-helix domain-containing protein	-
FCFHV36_RS10020	2004281..2004496	-	216	WP_001097552.1	hypothetical protein	-
FCFHV36_RS10025	2004551..2004916	+	366	WP_001128433.1	hypothetical protein	Antitoxin
FCFHV36_RS10030	2004885..2005130	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
FCFHV36_RS10035	2005197..2005577	+	381	WP_000773059.1	DUF2513 domain-containing protein	-
FCFHV36_RS10040	2005564..2005761	-	198	WP_001148860.1	hypothetical protein	-
FCFHV36_RS10045	2005831..2006043	+	213	WP_000362644.1	hypothetical protein	-
FCFHV36_RS16400	2006084..2006233	-	150	WP_000771849.1	hypothetical protein	-
FCFHV36_RS10050	2006248..2006691	-	444	WP_000435360.1	hypothetical protein	-
FCFHV36_RS10055	2006739..2006951	-	213	WP_000213811.1	helix-turn-helix transcriptional regulator	-
FCFHV36_RS10060	2007103..2007834	+	732	WP_000511090.1	XRE family transcriptional regulator	-
FCFHV36_RS15550	2007904..2008071	+	168	WP_000705238.1	hypothetical protein	-
FCFHV36_RS10070	2008211..2008891	+	681	WP_000392109.1	type II toxin-antitoxin system PemK/MazF family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1918599..2012128	93529

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T53565 WP_001025401.1 NZ_CP011147:c2005130-2004885 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T53565 NZ_CP011147:c2005130-2004885 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT53565 NZ_CP011147:2004551-2004916 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin