Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 5170753..5171357 Replicon chromosome
Accession NZ_CP011117
Organism Pseudomonas synxantha strain LBUM223

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag VO64_RS24320 Protein ID WP_046071432.1
Coordinates 5171043..5171357 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag VO64_RS24315 Protein ID WP_003189536.1
Coordinates 5170753..5171040 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VO64_RS24290 5166337..5167092 + 756 WP_046067917.1 IS21-like element ISPsy14 family helper ATPase IstB -
VO64_RS24300 5167601..5167852 + 252 WP_046071431.1 hypothetical protein -
VO64_RS24305 5167928..5169154 - 1227 WP_005786037.1 MFS transporter -
VO64_RS24310 5169347..5170597 + 1251 WP_046068046.1 IS256 family transposase -
VO64_RS24315 5170753..5171040 - 288 WP_003189536.1 helix-turn-helix domain-containing protein Antitoxin
VO64_RS24320 5171043..5171357 - 315 WP_046071432.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VO64_RS24325 5171463..5172404 - 942 WP_046071433.1 LysR family transcriptional regulator -
VO64_RS24330 5172562..5173878 + 1317 WP_046071434.1 MHS family MFS transporter -
VO64_RS24335 5173890..5175119 + 1230 WP_046071435.1 Zn-dependent hydrolase -
VO64_RS24340 5175131..5176168 + 1038 WP_046071436.1 histone deacetylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 5154154..5182240 28086


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(42-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-86)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11670.57 Da        Isoelectric Point: 10.0575

>T53453 WP_046071432.1 NZ_CP011117:c5171357-5171043 [Pseudomonas synxantha]
MIFIETSVFTRRVKELIDEDAYMALQNVLVVNPSAGDVIEGTGGVRKIRVAAKGHGKRGGARVIYYHFVSASQIVLLMIY
PKNEQQDLTAVERKSLKAAIEHWR

Download         Length: 315 bp

>T53453 NZ_CP011117:c5171357-5171043 [Pseudomonas synxantha]
ATGATTTTCATAGAGACGTCAGTCTTCACCCGTCGCGTTAAAGAATTGATCGACGAGGATGCCTACATGGCTCTTCAGAA
CGTGCTGGTAGTCAACCCTTCTGCTGGCGATGTGATTGAGGGTACGGGTGGAGTTCGCAAGATACGAGTAGCAGCCAAAG
GCCATGGCAAACGAGGCGGGGCGCGGGTGATCTATTACCATTTCGTCTCGGCATCACAGATTGTTTTACTGATGATCTAT
CCCAAAAATGAACAGCAGGACTTGACTGCCGTAGAGCGCAAGTCACTGAAGGCTGCGATTGAGCACTGGAGATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10828.41 Da        Isoelectric Point: 7.3219

>AT53453 WP_003189536.1 NZ_CP011117:c5171040-5170753 [Pseudomonas synxantha]
MSRFFDELMESVQEMNEILRGEREPSREFHVDSMRVKEIRKATGLTQAKFAALIDVQLGTLRNWEQGRREPTGPAKALLK
AIHNDPVHVLNALAS

Download         Length: 288 bp

>AT53453 NZ_CP011117:c5171040-5170753 [Pseudomonas synxantha]
ATGAGCAGATTTTTTGATGAACTGATGGAAAGCGTTCAAGAGATGAACGAGATCCTGCGCGGAGAACGCGAACCTTCTCG
TGAGTTCCATGTTGATTCAATGCGAGTCAAAGAGATCCGTAAGGCGACAGGGCTAACCCAGGCTAAATTCGCAGCGCTGA
TTGATGTGCAACTTGGCACGTTACGGAACTGGGAGCAGGGTCGTCGTGAGCCTACCGGACCAGCAAAGGCATTGTTGAAA
GCTATCCATAATGACCCAGTCCATGTACTGAATGCGTTGGCTAGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References