Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1037918..1038572 Replicon chromosome
Accession NZ_CP011117
Organism Pseudomonas synxantha strain LBUM223

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag VO64_RS04855 Protein ID WP_046068644.1
Coordinates 1037918..1038268 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0W0N117
Locus tag VO64_RS04860 Protein ID WP_014718915.1
Coordinates 1038258..1038572 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VO64_RS04845 1034677..1036209 + 1533 WP_034120261.1 NADH-quinone oxidoreductase subunit M -
VO64_RS04850 1036217..1037680 + 1464 WP_043046579.1 NADH-quinone oxidoreductase subunit NuoN -
VO64_RS04855 1037918..1038268 + 351 WP_046068644.1 toxin Toxin
VO64_RS04860 1038258..1038572 + 315 WP_014718915.1 XRE family transcriptional regulator Antitoxin
VO64_RS04865 1038632..1039384 - 753 WP_046068645.1 outer membrane beta-barrel protein -
VO64_RS04870 1039510..1040343 - 834 WP_046068646.1 arylamine N-acetyltransferase -
VO64_RS04875 1040462..1040698 + 237 WP_005789137.1 hypothetical protein -
VO64_RS04880 1040729..1040935 - 207 WP_046068647.1 hypothetical protein -
VO64_RS04885 1040948..1041127 - 180 WP_046068648.1 hypothetical protein -
VO64_RS04890 1041242..1041763 + 522 WP_046068649.1 DUF3087 domain-containing protein -
VO64_RS04895 1041771..1042901 - 1131 WP_046068650.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13794.71 Da        Isoelectric Point: 9.7336

>T53451 WP_046068644.1 NZ_CP011117:1037918-1038268 [Pseudomonas synxantha]
MDALFIELPAFERHRKDYLSEELFQGFQQELMKNPEAGDVIEGTGGLRKVRFVDERRNKGKRGGLRVIYYWWSGGTQFWL
FTLYGKHEHSDLTPHHKKALKHMLDREIKARTHHET

Download         Length: 351 bp

>T53451 NZ_CP011117:1037918-1038268 [Pseudomonas synxantha]
ATGGATGCTCTATTTATCGAACTGCCGGCATTCGAGCGGCATCGCAAGGACTATCTGAGTGAGGAGCTTTTCCAGGGTTT
TCAACAGGAGTTAATGAAAAACCCCGAAGCAGGAGATGTGATCGAAGGAACGGGCGGGTTGAGAAAGGTTCGCTTCGTTG
ATGAACGGCGAAACAAAGGCAAGCGTGGTGGCCTGCGAGTCATTTACTACTGGTGGTCAGGCGGCACGCAATTCTGGTTA
TTCACCTTGTACGGCAAGCACGAACATAGCGACCTGACACCCCACCACAAGAAAGCTCTTAAACACATGCTGGACAGGGA
AATCAAAGCGAGAACACATCATGAAACGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11755.58 Da        Isoelectric Point: 10.6525

>AT53451 WP_014718915.1 NZ_CP011117:1038258-1038572 [Pseudomonas synxantha]
MKRDIFSELVEGFDALADERQGKITLRNHKVHLNKLAPLTADEVIAVRQQLNLSRSVFAMYLRTNTRTLENWEQGRAKPN
AQAVTLIRLVARFPETVAQLAALG

Download         Length: 315 bp

>AT53451 NZ_CP011117:1038258-1038572 [Pseudomonas synxantha]
ATGAAACGTGACATCTTTTCCGAACTGGTCGAAGGCTTCGACGCCCTGGCCGATGAGCGCCAGGGTAAAATCACCCTGCG
CAACCACAAGGTCCACCTCAACAAGCTGGCGCCGCTCACCGCTGATGAGGTGATCGCCGTGCGCCAGCAACTCAACCTTT
CCCGGTCGGTATTCGCCATGTACCTGCGTACCAACACCCGCACCCTGGAGAACTGGGAACAAGGCCGGGCCAAGCCCAAC
GCCCAGGCCGTCACCCTGATCCGTCTGGTAGCGCGTTTTCCTGAAACCGTGGCGCAACTTGCCGCATTGGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0W0N117

References