53381

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 1332779..1333227 Replicon chromosome
Accession NZ_CP011108
Organism Thermotoga maritima strain Tma100

Toxin (Protein)


Gene name hicA Uniprot ID Q9X138
Locus tag THMB_RS06675 Protein ID WP_004079902.1
Coordinates 1332779..1333012 (-) Length 78 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID G4FE38
Locus tag THMB_RS06680 Protein ID WP_004079900.1
Coordinates 1333009..1333227 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
THMB_RS06640 1328297..1329103 + 807 WP_004079915.1 ABC transporter permease -
THMB_RS06650 1329321..1329755 + 435 WP_004079914.1 ABC transporter permease -
THMB_RS09865 1329759..1330529 + 771 Protein_1284 ABC transporter permease -
THMB_RS06665 1330592..1332334 + 1743 WP_004079909.1 ABC transporter ATP-binding protein/permease -
THMB_RS09780 1332405..1332554 - 150 WP_081434644.1 type II toxin-antitoxin system HicA family toxin -
THMB_RS06670 1332544..1332756 - 213 WP_004079908.1 hypothetical protein -
THMB_RS06675 1332779..1333012 - 234 WP_004079902.1 type II toxin-antitoxin system HicA family toxin Toxin
THMB_RS06680 1333009..1333227 - 219 WP_004079900.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
THMB_RS06685 1333324..1334931 - 1608 WP_010865307.1 helix-turn-helix domain-containing protein -
THMB_RS06690 1335127..1335291 + 165 WP_004083364.1 hypothetical protein -
THMB_RS06695 1335368..1335463 + 96 WP_010865309.1 Cys-rich RiPP peptide -
THMB_RS06700 1335565..1336956 + 1392 WP_004083362.1 radical SAM protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1325065..1336956 11891


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(10-65)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-56)


Sequences

Toxin        


Download         Length: 78 a.a.        Molecular weight: 8983.60 Da        Isoelectric Point: 10.4691

>T53381 WP_004079902.1 NZ_CP011108:c1333012-1332779 [Thermotoga maritima]
MSYLPIVDPKTMEKVLLKLGFQRVRQKGSHVFYRHSNGKYTTIPFHAKETCPSHLIRKIIREAGISVEEFKKVLENL

Download         Length: 234 bp

>T53381 NZ_CP011108:c1333012-1332779 [Thermotoga maritima]
TTGAGTTATCTTCCAATAGTTGATCCAAAAACTATGGAAAAGGTTTTACTGAAACTTGGATTTCAACGTGTTCGCCAAAA
AGGAAGTCATGTGTTCTACAGGCACAGCAATGGAAAGTATACGACCATCCCATTTCATGCAAAAGAGACTTGCCCAAGTC
ACTTAATAAGAAAAATCATCCGTGAAGCGGGTATATCAGTGGAGGAATTCAAGAAAGTACTTGAGAATCTGTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8186.38 Da        Isoelectric Point: 4.0891

>AT53381 WP_004079900.1 NZ_CP011108:c1333227-1333009 [Thermotoga maritima]
VRKIFTAIIEYDPEKKQYVGMVPDVPGVHTVGSSLEEVRRNLKEVLELVLEEAGDEINLQEFVALEMIEVET

Download         Length: 219 bp

>AT53381 NZ_CP011108:c1333227-1333009 [Thermotoga maritima]
GTGCGTAAAATTTTCACAGCTATCATTGAATACGATCCTGAAAAAAAGCAATATGTTGGAATGGTTCCAGATGTTCCAGG
TGTACATACTGTAGGTAGTTCCTTAGAAGAAGTGAGAAGGAATTTAAAAGAGGTGCTTGAACTCGTATTGGAGGAAGCAG
GAGATGAAATAAATCTCCAGGAATTCGTGGCTCTTGAGATGATAGAGGTGGAAACTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9X138

Antitoxin

Source ID Structure
AlphaFold DB G4FE38

References