Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 1227064..1227917 Replicon chromosome
Accession NZ_CP011105
Organism Legionella pneumophila strain L10-023 isolate Ulm

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag ULM_RS05555 Protein ID WP_042754999.1
Coordinates 1227064..1227570 (-) Length 169 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID -
Locus tag ULM_RS05560 Protein ID WP_042754998.1
Coordinates 1227570..1227917 (-) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ULM_RS05535 1222152..1222961 - 810 WP_042755003.1 integrase domain-containing protein -
ULM_RS17945 1223363..1223551 + 189 WP_136629085.1 hypothetical protein -
ULM_RS05540 1223565..1225337 - 1773 WP_042755002.1 ATP-binding protein -
ULM_RS05545 1225531..1225794 + 264 WP_042755001.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
ULM_RS17385 1225873..1226039 + 167 Protein_1102 type II toxin-antitoxin system YafQ family toxin -
ULM_RS05550 1226329..1226688 + 360 WP_042755000.1 MarR family transcriptional regulator -
ULM_RS05555 1227064..1227570 - 507 WP_042754999.1 type II toxin-antitoxin system YhaV family toxin Toxin
ULM_RS05560 1227570..1227917 - 348 WP_042754998.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
ULM_RS05565 1227987..1229237 - 1251 WP_042754997.1 tyrosine-type recombinase/integrase -
ULM_RS05570 1229720..1230586 + 867 WP_027220967.1 hypothetical protein -
ULM_RS05575 1230690..1231049 + 360 WP_032832446.1 hypothetical protein -
ULM_RS17390 1231094..1231333 - 240 WP_080454661.1 type II toxin-antitoxin system death-on-curing family toxin -
ULM_RS17950 1231312..1231467 - 156 WP_158649093.1 hypothetical protein -
ULM_RS05580 1231467..1231703 - 237 WP_027220969.1 hypothetical protein -
ULM_RS18105 1231990..1232223 - 234 WP_173644943.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - lem4/smdA / lpg1106 / ravL / ravM / lem5 / ravN / lem6 / ceg19 / lpg1124 / ravO / lpg1137 / cegC3 / lem7 / lpg1147 / lpg1148 / ravP / ravQ / lpg1158 / ravR 1124950..1348156 223206


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(14-150)

Antitoxin

PrlF antitoxin

(8-105)


Sequences

Toxin        


Download         Length: 169 a.a.        Molecular weight: 19527.21 Da        Isoelectric Point: 9.5699

>T53374 WP_042754999.1 NZ_CP011105:c1227570-1227064 [Legionella pneumophila]
MVDNSIITINGWVILCHPLFLQQVEALANEVEKAKEKDPSNFHTRNSTKKLAAIAKLAFEKIPNDPAATEFRQGSTLGNN
HKHWFRAKFFQQYRLFFRYHQESKIIIYAWVNDDSSKRAYESKADAYHIFRKMLENGHPPDNWDELLKEANNTSLMKKLT
TSLDALKS

Download         Length: 507 bp

>T53374 NZ_CP011105:c1227570-1227064 [Legionella pneumophila]
ATGGTTGATAATTCAATAATAACAATAAATGGCTGGGTTATTTTATGCCATCCTCTTTTTTTGCAACAGGTAGAGGCATT
GGCTAATGAGGTAGAAAAAGCAAAAGAAAAGGACCCTTCAAATTTTCATACACGAAACTCGACAAAAAAATTAGCAGCCA
TTGCTAAATTAGCTTTTGAAAAAATTCCAAACGATCCTGCAGCTACAGAATTTCGACAAGGATCAACATTAGGAAATAAC
CACAAACATTGGTTTCGAGCTAAATTTTTTCAGCAATATCGATTATTTTTTAGATACCATCAAGAAAGTAAAATAATTAT
TTATGCTTGGGTTAATGATGACAGTTCTAAAAGAGCATATGAAAGTAAAGCAGATGCTTATCATATTTTTCGAAAGATGC
TGGAAAATGGTCATCCTCCAGATAATTGGGATGAATTACTTAAAGAAGCAAATAACACTTCGTTAATGAAAAAATTGACT
ACCAGTTTGGATGCTTTGAAAAGTTAA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13175.84 Da        Isoelectric Point: 4.9405

>AT53374 WP_042754998.1 NZ_CP011105:c1227917-1227570 [Legionella pneumophila]
MARLLQTESTLTDRYQTTVPDAVRKALHLGKRDKIRYTVQSDGHVLMTRAEKEEDPVIAEFLNFIAKDIQNNPKNLTTIN
QDLVTRINSLVANVEVNLDEPLTEDEQLTENRVSR

Download         Length: 348 bp

>AT53374 NZ_CP011105:c1227917-1227570 [Legionella pneumophila]
ATGGCTAGATTACTACAAACCGAATCCACCCTCACAGATCGTTATCAAACAACTGTACCAGATGCTGTGAGAAAAGCCCT
GCATCTAGGAAAAAGAGATAAAATTCGATACACCGTTCAATCTGACGGTCATGTTCTTATGACTCGAGCAGAGAAAGAGG
AAGATCCAGTAATTGCTGAATTTTTGAATTTCATTGCTAAAGACATTCAAAATAACCCCAAAAATCTGACAACTATAAAT
CAGGATTTAGTAACTCGCATCAACTCTTTAGTTGCAAATGTTGAAGTCAATTTAGATGAACCTTTAACCGAGGATGAACA
ATTAACTGAAAACCGAGTAAGTCGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References