Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3858315..3859015 Replicon chromosome
Accession NZ_CP011104
Organism Photorhabdus thracensis strain DSM 15199

Toxin (Protein)


Gene name mqsR Uniprot ID T0PA00
Locus tag VY86_RS16605 Protein ID WP_021325247.1
Coordinates 3858315..3858611 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID A0A081RUY2
Locus tag VY86_RS16610 Protein ID WP_036840106.1
Coordinates 3858614..3859015 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VY86_RS24920 3854242..3854949 + 708 WP_158020040.1 phage tail protein -
VY86_RS16580 3854949..3855575 + 627 WP_046975785.1 tail fiber assembly protein -
VY86_RS16585 3855607..3855957 - 351 WP_046976929.1 tail fiber assembly protein -
VY86_RS16590 3855960..3856718 - 759 WP_046975786.1 hypothetical protein -
VY86_RS16595 3857182..3857502 + 321 WP_023044886.1 type II toxin-antitoxin system RelE/ParE family toxin -
VY86_RS16600 3857492..3857776 + 285 WP_023044887.1 helix-turn-helix domain-containing protein -
VY86_RS16605 3858315..3858611 + 297 WP_021325247.1 type II toxin-antitoxin system MqsR family toxin Toxin
VY86_RS16610 3858614..3859015 + 402 WP_036840106.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
VY86_RS23635 3859108..3859206 + 99 Protein_3299 CopG family transcriptional regulator -
VY86_RS16615 3860021..3861571 + 1551 WP_046975787.1 sulfatase-like hydrolase/transferase -
VY86_RS16620 3861699..3862354 - 656 Protein_3301 IS1595 family transposase -
VY86_RS16625 3862434..3863204 - 771 WP_036840104.1 glycosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3861699..3862181 482


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Antitoxin MqsA/HigA-2

(1-131)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11109.93 Da        Isoelectric Point: 6.7150

>T53365 WP_021325247.1 NZ_CP011104:3858315-3858611 [Photorhabdus thracensis]
MEKRTPHCKLSVVKTLIEARKVRTTYTALAGANELGLEFSDMLAIVMALTPADFYKSMTTYADHTVWQDVYRPNTHVGDV
YLKLTVIDDVLIVSFKEL

Download         Length: 297 bp

>T53365 NZ_CP011104:3858315-3858611 [Photorhabdus thracensis]
ATGGAAAAACGAACACCACATTGTAAGTTATCAGTTGTCAAAACTTTGATCGAAGCCAGAAAAGTACGTACCACATATAC
AGCGCTAGCTGGTGCGAATGAGCTGGGACTTGAGTTCTCCGACATGCTAGCCATAGTGATGGCGCTCACGCCAGCGGATT
TCTACAAGAGTATGACGACTTACGCTGATCATACGGTCTGGCAAGACGTGTACCGGCCAAACACACATGTGGGTGATGTG
TATCTGAAGCTGACGGTCATTGATGACGTGCTGATCGTGTCCTTCAAGGAGCTATAA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14617.80 Da        Isoelectric Point: 6.4492

>AT53365 WP_036840106.1 NZ_CP011104:3858614-3859015 [Photorhabdus thracensis]
MKCPFCSTAELIHDTRDLPYTYKGETTIISAVTGDFCPACSESVLDAAESERVMCEMRAFSKQVNAAIVDPSFIASVRKK
LALDQREASEIFGGGINAFSRYENGKTKPSLALVKLLKVLDRHPDLLSEIRTA

Download         Length: 402 bp

>AT53365 NZ_CP011104:3858614-3859015 [Photorhabdus thracensis]
ATGAAATGTCCTTTTTGCAGCACAGCGGAACTTATCCACGATACGCGCGATCTACCCTATACATACAAGGGCGAAACCAC
AATCATTTCTGCTGTAACGGGCGACTTCTGCCCTGCCTGCTCCGAATCTGTTTTGGACGCTGCGGAATCAGAGCGTGTTA
TGTGCGAAATGCGCGCATTTTCGAAGCAGGTCAACGCAGCTATTGTCGATCCTAGCTTCATTGCCAGTGTGCGTAAAAAA
CTCGCACTTGACCAGCGAGAAGCCTCTGAAATCTTCGGCGGTGGTATCAATGCTTTCTCGCGCTACGAGAATGGCAAGAC
TAAACCGTCGCTAGCTTTAGTGAAGCTGCTTAAGGTGTTAGATCGTCACCCCGATTTGCTCTCTGAAATCAGAACGGCGT
AA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB T0PA00

Antitoxin

Source ID Structure
AlphaFold DB A0A081RUY2

References