Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 2202904..2203436 Replicon chromosome
Accession NZ_CP011104
Organism Photorhabdus thracensis strain DSM 15199

Toxin (Protein)


Gene name yafQ Uniprot ID A0A0F7LNX5
Locus tag VY86_RS09440 Protein ID WP_046974780.1
Coordinates 2203164..2203436 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID T0P9U3
Locus tag VY86_RS09435 Protein ID WP_021325378.1
Coordinates 2202904..2203164 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VY86_RS09420 2199038..2199595 - 558 WP_046974777.1 DNA-3-methyladenine glycosylase I -
VY86_RS09425 2199791..2200705 + 915 WP_046974778.1 glycine--tRNA ligase subunit alpha -
VY86_RS09430 2200715..2202784 + 2070 WP_046974779.1 glycine--tRNA ligase subunit beta -
VY86_RS09435 2202904..2203164 + 261 WP_021325378.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
VY86_RS09440 2203164..2203436 + 273 WP_046974780.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
VY86_RS09450 2203985..2205067 - 1083 WP_046976791.1 methyltransferase domain-containing protein -
VY86_RS09455 2205194..2205487 - 294 WP_052760808.1 PadR family transcriptional regulator -
VY86_RS09460 2206105..2206350 - 246 Protein_1856 cytochrome P450 -
VY86_RS09465 2206487..2207524 - 1038 WP_046976644.1 IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-88)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10840.50 Da        Isoelectric Point: 10.5131

>T53359 WP_046974780.1 NZ_CP011104:2203164-2203436 [Photorhabdus thracensis]
MRQPRYSSQFKRDVKSAQKRGKDMNKLKVLMRLLIDNRPLPANYQDHLLRGEWKAFRDAHIEPDWLLIYKVVGDVVRFER
TGRHSDLFDE

Download         Length: 273 bp

>T53359 NZ_CP011104:2203164-2203436 [Photorhabdus thracensis]
ATGCGTCAGCCAAGATATTCAAGTCAATTTAAGCGTGATGTGAAATCCGCACAAAAACGTGGCAAAGATATGAACAAACT
TAAGGTCCTAATGCGTTTGTTGATTGATAATAGACCATTGCCTGCTAACTATCAGGATCATCTTCTCCGTGGTGAATGGA
AGGCGTTTCGTGATGCTCACATTGAGCCTGATTGGTTATTGATTTACAAAGTAGTTGGTGATGTCGTTAGGTTTGAACGA
ACAGGAAGACATTCTGACCTATTTGATGAATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9398.82 Da        Isoelectric Point: 4.8232

>AT53359 WP_021325378.1 NZ_CP011104:2202904-2203164 [Photorhabdus thracensis]
MAANAFVRARIDETLKAEATEVLAGMGLTISDLVRITLTKVAKEKALPFEMRVPNKLTAETLAKSDRGEDIHQAKDADDL
FDQLGI

Download         Length: 261 bp

>AT53359 NZ_CP011104:2202904-2203164 [Photorhabdus thracensis]
ATGGCTGCAAATGCATTTGTTCGGGCAAGAATCGATGAGACATTAAAAGCAGAAGCTACCGAAGTTTTGGCTGGTATGGG
GTTAACCATATCTGATCTTGTGCGTATCACCTTGACTAAAGTTGCGAAGGAAAAAGCATTACCGTTTGAAATGAGAGTAC
CTAATAAATTGACTGCCGAAACTTTGGCTAAGAGTGATCGTGGTGAAGACATTCATCAAGCAAAGGATGCTGACGATTTA
TTCGATCAGCTTGGTATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F7LNX5

Antitoxin

Source ID Structure
AlphaFold DB T0P9U3

References