Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 906117..906769 Replicon chromosome
Accession NZ_CP011104
Organism Photorhabdus thracensis strain DSM 15199

Toxin (Protein)


Gene name higB Uniprot ID A0A0F7LL94
Locus tag VY86_RS03785 Protein ID WP_046973983.1
Coordinates 906117..906467 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0F7LKP7
Locus tag VY86_RS03790 Protein ID WP_046973984.1
Coordinates 906470..906769 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VY86_RS03765 901643..904096 + 2454 WP_046973979.1 bifunctional glycosyl transferase/transpeptidase -
VY86_RS03770 904323..904898 - 576 WP_046973980.1 carbonic anhydrase -
VY86_RS03775 905227..905487 + 261 WP_046973981.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
VY86_RS03780 905484..905882 + 399 WP_046973982.1 type II toxin-antitoxin system VapC family toxin -
VY86_RS03785 906117..906467 + 351 WP_046973983.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VY86_RS03790 906470..906769 + 300 WP_046973984.1 XRE family transcriptional regulator Antitoxin
VY86_RS24465 906828..907163 - 336 Protein_740 IS982 family transposase -
VY86_RS03795 907199..908482 - 1284 WP_046973985.1 glutamate-1-semialdehyde 2,1-aminomutase -
VY86_RS03800 908533..909318 - 786 WP_046973986.1 DUF1460 domain-containing protein -
VY86_RS03805 909733..910077 + 345 WP_031280637.1 iron-sulfur cluster insertion protein ErpA -
VY86_RS03810 910200..910601 - 402 Protein_744 IS200/IS605 family transposase -
VY86_RS25300 910660..911604 + 945 Protein_745 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13439.49 Da        Isoelectric Point: 5.7736

>T53353 WP_046973983.1 NZ_CP011104:906117-906467 [Photorhabdus thracensis]
MWEVITTECFDEWFLAQEDALRESVYEAMGVLEKFGPKLGRPYVDTLSGSDFPNMKELRVQHAGNPIRAFFAFDPIRCAI
ILCAGDKTGLNEKRFYKDMIRIADSEYRKHLAKLEK

Download         Length: 351 bp

>T53353 NZ_CP011104:906117-906467 [Photorhabdus thracensis]
ATGTGGGAAGTCATAACGACGGAGTGCTTTGATGAGTGGTTCTTGGCTCAGGAAGATGCTCTAAGGGAGTCAGTCTATGA
AGCTATGGGGGTATTGGAAAAGTTCGGCCCAAAACTTGGCAGACCATATGTTGATACATTGAGTGGTTCTGATTTCCCTA
ACATGAAGGAGCTGCGTGTACAACATGCTGGTAATCCTATCAGAGCGTTTTTTGCGTTTGATCCTATCCGGTGCGCAATT
ATTTTGTGTGCTGGCGATAAAACGGGATTAAATGAGAAACGTTTCTATAAGGATATGATTCGGATAGCTGATTCCGAGTA
CCGTAAACATCTTGCGAAACTGGAGAAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11076.84 Da        Isoelectric Point: 6.3661

>AT53353 WP_046973984.1 NZ_CP011104:906470-906769 [Photorhabdus thracensis]
MATYRELLAKESPEMQARVAERIEEASIQIALSQLRDELKISQTELAAIMGVKQPSVARMEQADNDPRLSTLKRYVKALG
GELSLDVTLPTGKRVVFYL

Download         Length: 300 bp

>AT53353 NZ_CP011104:906470-906769 [Photorhabdus thracensis]
ATGGCTACTTACAGAGAACTGTTGGCTAAAGAAAGTCCTGAAATGCAGGCACGAGTTGCGGAACGGATTGAAGAAGCCAG
TATCCAGATCGCCCTTAGCCAACTGCGTGATGAGCTAAAAATTTCACAAACAGAATTGGCCGCTATTATGGGGGTCAAAC
AGCCTTCCGTTGCTCGTATGGAACAAGCTGACAATGATCCAAGGCTATCAACACTTAAGCGCTATGTGAAAGCATTGGGC
GGTGAATTAAGCCTTGATGTGACTCTTCCAACAGGTAAGCGCGTAGTTTTCTACCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F7LL94

Antitoxin

Source ID Structure
AlphaFold DB A0A0F7LKP7

References