Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2550350..2550995 Replicon chromosome
Accession NZ_CP011047
Organism Cronobacter sakazakii strain ATCC 29544

Toxin (Protein)


Gene name higB Uniprot ID A0A7V7RET2
Locus tag CSK29544_RS12170 Protein ID WP_029039286.1
Coordinates 2550350..2550712 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A7V7REZ4
Locus tag CSK29544_RS12175 Protein ID WP_007902969.1
Coordinates 2550699..2550995 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSK29544_RS12160 2545750..2548872 - 3123 WP_007902982.1 MdtB/MuxB family multidrug efflux RND transporter permease subunit -
CSK29544_RS12165 2548872..2550119 - 1248 WP_007902978.1 MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit -
CSK29544_RS12170 2550350..2550712 + 363 WP_029039286.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CSK29544_RS12175 2550699..2550995 + 297 WP_007902969.1 helix-turn-helix transcriptional regulator Antitoxin
CSK29544_RS12180 2551005..2552357 - 1353 WP_007902966.1 molecular chaperone -
CSK29544_RS12185 2552493..2553341 + 849 WP_007902962.1 DNA-3-methyladenine glycosylase 2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

HigA2-like, helix-turn-helix domain

(7-87)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 14211.10 Da        Isoelectric Point: 8.0154

>T53216 WP_029039286.1 NZ_CP011047:2550350-2550712 [Cronobacter sakazakii]
MAWTVIFTDRFNDWYQQQPEGLQDRIAALLWNLRYSGPLVGRPLVDTVKGSRYPNLKELRVQYGGEPWRIFFAFDAERQA
VVLCAGNKRSQKHFYDALIRQAEEEFFLHVQAMERRNENS

Download         Length: 363 bp

>T53216 NZ_CP011047:2550350-2550712 [Cronobacter sakazakii]
ATGGCATGGACGGTGATTTTTACCGATCGTTTTAACGACTGGTATCAGCAGCAGCCCGAAGGATTACAGGATCGTATCGC
CGCGCTCTTATGGAACTTACGTTATTCCGGCCCGCTTGTCGGACGCCCGCTGGTCGATACGGTGAAAGGTTCGCGTTATC
CCAACCTGAAAGAGCTACGTGTGCAATATGGCGGTGAGCCCTGGCGCATTTTTTTTGCGTTTGACGCTGAACGTCAGGCC
GTTGTGCTCTGCGCAGGCAATAAACGAAGCCAGAAACATTTTTATGACGCCTTAATCAGGCAGGCTGAAGAAGAATTCTT
CCTGCATGTGCAAGCGATGGAGAGACGAAATGAAAACTCTTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10794.72 Da        Isoelectric Point: 5.1667

>AT53216 WP_007902969.1 NZ_CP011047:2550699-2550995 [Cronobacter sakazakii]
MKTLDDVMAGFSPERQAEILRMADEIALEHGLPLIREARAFSQQQLAEIMGVTQPAIAAIEQRGKEIKLLTLKRYVEALG
GKLSLLIELPEGSKVIPV

Download         Length: 297 bp

>AT53216 NZ_CP011047:2550699-2550995 [Cronobacter sakazakii]
ATGAAAACTCTTGATGACGTAATGGCGGGCTTTTCCCCGGAACGGCAGGCAGAAATCCTGCGCATGGCAGACGAAATCGC
GCTGGAGCACGGCCTGCCGCTCATTCGCGAAGCGCGGGCGTTTTCGCAGCAGCAACTGGCGGAGATAATGGGCGTGACGC
AGCCCGCTATCGCCGCCATTGAGCAGCGCGGGAAGGAGATCAAACTGCTGACGCTCAAGCGCTACGTTGAAGCGCTGGGC
GGCAAGCTCTCTTTACTGATAGAGCTGCCCGAAGGCAGCAAAGTGATCCCCGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7V7RET2

Antitoxin

Source ID Structure
AlphaFold DB A0A7V7REZ4

References