Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4139706..4140294 Replicon chromosome
Accession NZ_CP011010
Organism Stenotrophomonas maltophilia strain ISMMS3 isolate Patient

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag VN11_RS18830 Protein ID WP_053450845.1
Coordinates 4140016..4140294 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag VN11_RS18825 Protein ID WP_006471116.1
Coordinates 4139706..4140005 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VN11_RS18805 4135175..4136362 + 1188 WP_053450842.1 pyridoxal phosphate-dependent aminotransferase -
VN11_RS18810 4136450..4138546 - 2097 WP_053450843.1 prolyl oligopeptidase family protein -
VN11_RS18815 4138616..4138942 - 327 WP_053450844.1 hypothetical protein -
VN11_RS18820 4139070..4139666 + 597 WP_080374966.1 lipocalin family protein -
VN11_RS18825 4139706..4140005 - 300 WP_006471116.1 HigA family addiction module antidote protein Antitoxin
VN11_RS18830 4140016..4140294 - 279 WP_053450845.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VN11_RS18835 4140494..4141183 - 690 WP_006471118.1 ABC transporter permease -
VN11_RS18840 4141180..4142187 - 1008 WP_006471119.1 methionine ABC transporter ATP-binding protein -
VN11_RS18845 4142335..4143231 - 897 WP_006471120.1 DMT family transporter -
VN11_RS18850 4143445..4143927 + 483 WP_006471121.1 YajQ family cyclic di-GMP-binding protein -
VN11_RS18855 4144029..4144595 + 567 WP_053451384.1 DUF1415 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(25-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-66)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10740.27 Da        Isoelectric Point: 10.4115

>T53170 WP_053450845.1 NZ_CP011010:c4140294-4140016 [Stenotrophomonas maltophilia]
MIRSFRCKQTRALFEGTCPRAWRPIRRVAERKLQLLDSAQTLAFLRSPPGNRLEALSGDRRGQYSLRINDQWRLCFTWTD
SGADAVEIVDYH

Download         Length: 279 bp

>T53170 NZ_CP011010:c4140294-4140016 [Stenotrophomonas maltophilia]
ATGATCCGTTCATTCCGCTGCAAGCAGACCCGCGCCCTGTTTGAAGGAACCTGCCCCCGTGCCTGGCGTCCAATCCGGCG
CGTGGCAGAACGCAAATTGCAACTGCTCGATTCGGCACAGACGTTGGCCTTCCTTCGCAGCCCGCCCGGGAACCGCCTGG
AGGCGCTGTCAGGCGATCGGAGAGGGCAATACAGCCTTCGTATCAACGATCAGTGGCGGCTCTGCTTTACCTGGACCGAC
AGCGGCGCCGACGCCGTGGAAATTGTTGACTATCACTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10869.59 Da        Isoelectric Point: 11.3450

>AT53170 WP_006471116.1 NZ_CP011010:c4140005-4139706 [Stenotrophomonas maltophilia]
MKRPHNGMRAIHPGEILREEFLLPLALSVNALAKALDVPATRLHAIVHGQRSISADTAARLARHFGGDAASWLAMQAAYD
LKTLPTRSEIERRVQPRAA

Download         Length: 300 bp

>AT53170 NZ_CP011010:c4140005-4139706 [Stenotrophomonas maltophilia]
ATGAAGCGTCCCCACAACGGCATGCGCGCCATCCATCCTGGCGAGATCCTGCGCGAAGAGTTCCTGCTGCCCCTGGCGCT
GAGCGTGAATGCGCTGGCGAAGGCCTTGGATGTGCCCGCAACGCGACTGCACGCCATCGTGCACGGCCAACGCAGCATTT
CGGCGGATACAGCGGCGCGGCTGGCGCGGCATTTCGGTGGGGATGCCGCGTCCTGGCTCGCGATGCAGGCGGCCTACGAT
CTGAAGACCTTGCCAACACGCAGCGAAATCGAACGCCGGGTGCAGCCACGCGCGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References