Detailed information of TA system TA053163

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 1673375..1673559
• Replicon: chromosome
• Accession: NZ_CP010998
• Organism: Staphylococcus aureus strain FORC_012 isolate human sputum

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: FORC12_RS08750
• Protein ID: WP_000482650.1
• Coordinates: 1673452..1673559 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	1673375..1673435 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC12_RS08725	1668885..1669052	-	168	WP_001792506.1	hypothetical protein	-
FORC12_RS08735	1669283..1671016	-	1734	WP_000486494.1	ABC transporter ATP-binding protein/permease	-
FORC12_RS08740	1671041..1672804	-	1764	WP_001064820.1	ABC transporter ATP-binding protein/permease	-
-	1673375..1673435	+	61	-	-	Antitoxin
FORC12_RS08750	1673452..1673559	-	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
FORC12_RS08755	1673693..1674079	-	387	WP_000779358.1	flippase GtxA	-
FORC12_RS08760	1674337..1675479	+	1143	WP_001176863.1	glycerate kinase	-
FORC12_RS08765	1675539..1676198	+	660	WP_000831298.1	membrane protein	-
FORC12_RS08770	1676380..1677591	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
FORC12_RS08775	1677714..1678187	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-24)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T53163 WP_000482650.1 NZ_CP010998:c1673559-1673452 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T53163 NZ_CP010998:c1673559-1673452 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT53163 NZ_CP010998:1673375-1673435 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin