Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 1391899..1392115 Replicon chromosome
Accession NZ_CP010998
Organism Staphylococcus aureus strain FORC_012 isolate human sputum

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag FORC12_RS07265 Protein ID WP_001802298.1
Coordinates 1392011..1392115 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 1391899..1391954 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC12_RS07245 1388102..1388767 - 666 WP_001024095.1 SDR family oxidoreductase -
FORC12_RS07250 1388919..1389239 + 321 WP_000003755.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
FORC12_RS07255 1389241..1390221 + 981 WP_000019743.1 CDF family zinc efflux transporter CzrB -
FORC12_RS07260 1390487..1391578 + 1092 WP_000495681.1 hypothetical protein -
- 1391899..1391954 + 56 - - Antitoxin
FORC12_RS07265 1392011..1392115 - 105 WP_001802298.1 hypothetical protein Toxin
FORC12_RS14505 1392795..1392953 + 159 WP_001792784.1 hypothetical protein -
FORC12_RS07270 1393611..1394468 - 858 WP_000370928.1 Cof-type HAD-IIB family hydrolase -
FORC12_RS07275 1394536..1395318 - 783 WP_000908189.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T53160 WP_001802298.1 NZ_CP010998:c1392115-1392011 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T53160 NZ_CP010998:c1392115-1392011 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 56 bp

>AT53160 NZ_CP010998:1391899-1391954 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References