Detailed information of TA system TA053156

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF4/-
• Location: 1218971..1219270
• Replicon: chromosome
• Accession: NZ_CP010998
• Organism: Staphylococcus aureus strain FORC_012 isolate human sputum

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: FORC12_RS14460
• Protein ID: WP_011447039.1
• Coordinates: 1219094..1219270 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	1218971..1219026 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC12_RS06270	1214313..1214573	+	261	WP_001791826.1	hypothetical protein	-
FORC12_RS06275	1214626..1214966	-	341	Protein_1177	complement inhibitor SCIN-A	-
FORC12_RS06280	1215650..1216099	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
FORC12_RS14970	1216194..1216529	-	336	Protein_1179	SH3 domain-containing protein	-
FORC12_RS06290	1217179..1217670	-	492	WP_000919350.1	staphylokinase	-
FORC12_RS06295	1217861..1218616	-	756	WP_000861038.1	CHAP domain-containing protein	-
FORC12_RS06300	1218628..1218882	-	255	WP_000611512.1	phage holin	-
FORC12_RS06305	1218934..1219041	+	108	WP_001791821.1	hypothetical protein	-
-	1218963..1219102	+	140	NuclAT_0	-	-
-	1218963..1219102	+	140	NuclAT_0	-	-
-	1218963..1219102	+	140	NuclAT_0	-	-
-	1218963..1219102	+	140	NuclAT_0	-	-
-	1218971..1219026	+	56	-	-	Antitoxin
FORC12_RS14460	1219094..1219270	-	177	WP_011447039.1	putative holin-like toxin	Toxin
FORC12_RS06310	1219420..1219716	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
FORC12_RS06315	1219774..1220061	-	288	WP_001040261.1	hypothetical protein	-
FORC12_RS06320	1220108..1220260	-	153	WP_001153681.1	hypothetical protein	-
FORC12_RS06325	1220250..1224035	-	3786	WP_000582165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / scn / chp / sak / hlb	1214626..1259007	44381

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T53156 WP_011447039.1 NZ_CP010998:c1219270-1219094 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T53156 NZ_CP010998:c1219270-1219094 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT53156 NZ_CP010998:1218971-1219026 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin