Detailed information of TA system TA053076

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): HipBST/HipA(toxin)
• Location: 2847862..2849165
• Replicon: chromosome
• Accession: NZ_CP010904
• Organism: Kiritimatiella glycovorans strain L21-Fru-AB

Toxin (Protein)

• Gene name: HipT
• Uniprot ID: A0A0G3EGN3
• Locus tag: L21SP4_RS11795
• Protein ID: WP_052882839.1
• Coordinates: 2847862..2848800 (-)
• Length: 313 a.a.

Antitoxin (Protein)

• Gene name: HipS
• Uniprot ID: -
• Locus tag: L21SP4_RS11800
• Protein ID: WP_052882840.1
• Coordinates: 2848803..2849165 (-)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L21SP4_RS11775	2843439..2843606	+	168	WP_201774639.1	DUF4160 domain-containing protein	-
L21SP4_RS11780	2843622..2844236	-	615	WP_052882836.1	hypothetical protein	-
L21SP4_RS11785	2844433..2844651	-	219	WP_052882837.1	hypothetical protein	-
L21SP4_RS11790	2844808..2847495	-	2688	WP_052882838.1	discoidin domain-containing protein	-
L21SP4_RS11795	2847862..2848800	-	939	WP_052882839.1	HipA domain-containing protein	Toxin
L21SP4_RS11800	2848803..2849165	-	363	WP_052882840.1	HipA N-terminal domain-containing protein	Antitoxin
L21SP4_RS12625	2849162..2849401	-	240	WP_074041493.1	helix-turn-helix transcriptional regulator	-
L21SP4_RS11805	2849941..2852463	-	2523	WP_052882841.1	discoidin domain-containing protein	-
L21SP4_RS11810	2852728..2853501	-	774	WP_052882842.1	PEP-CTERM sorting domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (53-277)

Antitoxin

• HipA, N-terminal subdomain 1 (13-107)

Sequences

Toxin

Protein

• Length: 313 a.a.
• Molecular weight: 35461.09 Da
• Isoelectric Point: 9.1134

>T53076 WP_052882839.1 NZ_CP010904:c2848800-2847862 [Kiritimatiella glycovorans]
MSHCPINLESLPEGCKYSETGLKSIHPKLKHLKPFEYSYEEQLREVRRRSGKMSIQGVQPKLSAVLKLKDASFALVNRGG
RFILKPNPLACEEVPANEALTMSMAAAAGIHVPVHGLLCAQDDSWVYFVKRYDREGRSKKVHVEDFAQLSASTRETKYDS
SLERVAQLVEQFCTFPAIEKPKLAKRLLFCFLTGNEDMHLKNFSIWVQDGVVSLTPAYDLLNSTLVLENAKEESALPLHG
KKKKLTKKLWLDYFCRDRLKLSEVQVDKILQDFQEAMPAFDGLIGRSFLSEERKAGYRDILLERVRRLGISG

Nucleotide

• Length: 939 bp

>T53076 NZ_CP010904:c2848800-2847862 [Kiritimatiella glycovorans]
ATGTCGCATTGTCCGATCAATTTAGAGTCATTGCCTGAGGGATGCAAATATTCGGAAACTGGCCTGAAGAGCATACACCC
GAAGCTGAAGCATTTGAAGCCTTTCGAGTATTCGTATGAAGAACAACTTCGTGAAGTGCGTCGCCGCTCCGGTAAGATGT
CTATTCAAGGTGTGCAGCCCAAGCTATCGGCTGTTTTAAAATTAAAAGATGCTTCCTTCGCATTGGTGAACCGAGGAGGG
AGATTTATTTTGAAACCCAACCCATTGGCATGCGAAGAAGTACCCGCCAATGAGGCGCTGACGATGAGTATGGCTGCGGC
TGCGGGTATTCATGTGCCTGTGCATGGCTTATTGTGTGCTCAGGATGATAGCTGGGTTTATTTTGTGAAGCGCTATGACC
GTGAGGGGCGTTCAAAGAAAGTGCACGTGGAGGACTTTGCGCAACTTTCAGCGTCAACCCGTGAAACAAAGTATGACAGC
TCTTTGGAGCGTGTCGCTCAGTTGGTCGAACAATTTTGCACCTTTCCGGCGATAGAAAAGCCCAAGTTGGCCAAGCGTCT
GTTGTTCTGCTTCCTGACTGGCAATGAAGATATGCACCTGAAAAATTTCTCGATTTGGGTGCAGGACGGAGTGGTCTCTT
TAACGCCTGCGTATGACCTCTTGAATTCGACTCTGGTTTTGGAGAATGCCAAGGAAGAGAGTGCGTTGCCTTTGCATGGT
AAAAAGAAGAAGCTCACCAAAAAGTTATGGTTGGATTACTTTTGCCGTGATCGTTTGAAGCTATCGGAAGTGCAGGTTGA
TAAAATTCTCCAAGACTTTCAGGAGGCTATGCCTGCATTTGACGGCTTGATTGGGCGAAGCTTCCTATCAGAAGAGCGTA
AGGCTGGATACCGTGATATCCTGTTGGAAAGAGTAAGAAGGTTGGGGATTTCGGGATAA

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 13163.01 Da
• Isoelectric Point: 4.4821

>AT53076 WP_052882840.1 NZ_CP010904:c2849165-2848803 [Kiritimatiella glycovorans]
MTDGDKKVLRRAEVFQSGRLAGNLLEQEQGGLWVFEYIDGYGGAPISLTLPVRGEPYTFKEFPAVFDGLLPEGAQLEALL
KTRKIDRNDYFKQLVTVGGDLVGSLSVCIPKDAIAEEKEG

Nucleotide

• Length: 363 bp

>AT53076 NZ_CP010904:c2849165-2848803 [Kiritimatiella glycovorans]
ATGACGGACGGCGACAAAAAAGTTCTTCGAAGAGCGGAGGTCTTCCAGTCAGGACGGCTTGCCGGAAATTTATTGGAGCA
GGAGCAAGGTGGTCTTTGGGTTTTCGAGTATATAGATGGCTATGGAGGTGCGCCTATTTCACTGACACTTCCCGTTCGTG
GGGAGCCTTATACATTCAAGGAGTTTCCTGCCGTTTTTGATGGATTGCTGCCTGAAGGGGCGCAATTGGAAGCGCTCTTG
AAGACACGCAAGATTGATCGAAATGACTATTTTAAGCAGTTGGTGACTGTCGGAGGCGATTTAGTCGGTTCGCTTTCAGT
GTGTATCCCAAAGGATGCTATTGCTGAGGAAAAGGAAGGCTAG

Structures

Toxin

• AlphaFold DB: A0A0G3EGN3