Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 61212..61797 Replicon plasmid p6411-66.409kb
Accession NZ_CP010903
Organism Acinetobacter nosocomialis strain 6411

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag RR32_RS19175 Protein ID WP_050049568.1
Coordinates 61212..61532 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag RR32_RS19180 Protein ID WP_000369781.1
Coordinates 61525..61797 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RR32_RS19145 56710..57618 - 909 WP_050049564.1 replication initiation protein RepM -
RR32_RS19150 58748..58939 + 192 WP_000102617.1 hypothetical protein -
RR32_RS19155 58989..59192 + 204 WP_000272278.1 hypothetical protein -
RR32_RS19160 59623..59937 + 315 WP_050049565.1 helix-turn-helix domain-containing protein -
RR32_RS19165 59973..60293 + 321 WP_050049566.1 hypothetical protein -
RR32_RS19170 60781..61095 - 315 WP_050049567.1 hypothetical protein -
RR32_RS19175 61212..61532 + 321 WP_050049568.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
RR32_RS19180 61525..61797 + 273 WP_000369781.1 helix-turn-helix domain-containing protein Antitoxin
RR32_RS19185 62023..63348 + 1326 WP_050049569.1 protein kinase -
RR32_RS19190 63421..63732 - 312 WP_050049570.1 BrnA antitoxin family protein -
RR32_RS19195 63719..64006 - 288 WP_050049571.1 BrnT family toxin -
RR32_RS19200 64276..65496 + 1221 WP_050049572.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..66409 66409


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-85)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12193.01 Da        Isoelectric Point: 7.9834

>T53072 WP_050049568.1 NZ_CP010903:61212-61532 [Acinetobacter nosocomialis]
MLFIETSIFTKQIKDLVSDEEYRQLQQDLLIQPDKGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETAILRQLVKEQFHG

Download         Length: 321 bp

>T53072 NZ_CP010903:61212-61532 [Acinetobacter nosocomialis]
ATGTTATTCATTGAAACTAGCATCTTTACCAAGCAAATTAAAGACCTTGTATCTGATGAGGAATACCGCCAACTTCAACA
AGATCTTTTGATTCAGCCTGATAAAGGTGATCTTATCAAAAATGGCGGTGGTATTCGCAAAGTACGTTGTGCTCAAGGTA
ACAAAGGGAAAAGTGGCGGAATACGAGTGATTTATTATTGGGTCACCGAGGACGATCAAATCTTTTTCTTAGTGGCTTAT
CCAAAATCAGTGAAAGATAACTTAACTGATAAGGAAACAGCCATTCTGCGCCAACTCGTGAAGGAGCAATTTCATGGATA
A

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10149.61 Da        Isoelectric Point: 8.6582

>AT53072 WP_000369781.1 NZ_CP010903:61525-61797 [Acinetobacter nosocomialis]
MDNNLFDDLVASIKEAGAIKRKEVKASRVTELELPDIKEVREKTGLSQNEFAARLHISPRTLQNWEQGRRYPTGPAATLI
RILDAHPSLI

Download         Length: 273 bp

>AT53072 NZ_CP010903:61525-61797 [Acinetobacter nosocomialis]
ATGGATAACAACTTATTTGATGACTTGGTTGCTTCAATCAAAGAAGCTGGAGCTATCAAACGTAAAGAGGTAAAAGCAAG
CCGAGTTACAGAACTCGAATTGCCTGATATTAAAGAAGTACGTGAAAAAACTGGCTTAAGCCAAAATGAGTTTGCTGCAC
GCTTGCATATTAGCCCTCGGACCTTACAGAACTGGGAACAGGGACGACGCTATCCAACTGGACCAGCAGCTACATTAATT
CGAATTTTAGATGCTCACCCAAGCCTTATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References