Detailed information of TA system TA053042

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1854718..1854898
• Replicon: chromosome
• Accession: NZ_CP010890
• Organism: Staphylococcus aureus strain SA564

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: RT87_RS14910
• Protein ID: WP_001801861.1
• Coordinates: 1854718..1854813 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1854841..1854898 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RT87_RS09045	1849881..1850531	+	651	WP_001795210.1	excalibur calcium-binding domain-containing protein	-
RT87_RS09050	1850612..1851607	+	996	WP_000070642.1	DUF4352 domain-containing protein	-
RT87_RS09055	1851682..1852308	+	627	WP_000669024.1	hypothetical protein	-
RT87_RS09060	1852349..1852690	+	342	WP_000627540.1	DUF3969 family protein	-
RT87_RS09065	1852791..1853363	+	573	WP_000414216.1	hypothetical protein	-
RT87_RS14565	1853561..1854573	-	1013	Protein_1743	IS3 family transposase	-
RT87_RS14910	1854718..1854813	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1854841..1854898	-	58	-	-	Antitoxin
RT87_RS09085	1854936..1855037	+	102	WP_001792025.1	hypothetical protein	-
RT87_RS14915	1855015..1855176	-	162	Protein_1746	transposase	-
RT87_RS09090	1855167..1855661	-	495	Protein_1747	transposase	-
RT87_RS09095	1856113..1857342	-	1230	WP_000072627.1	restriction endonuclease subunit S	-
RT87_RS09100	1857335..1858891	-	1557	WP_000028669.1	type I restriction-modification system subunit M	-
RT87_RS09105	1859055..1859189	-	135	WP_001791797.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA / selk	1830700..1881730	51030

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T53042 WP_001801861.1 NZ_CP010890:1854718-1854813 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T53042 NZ_CP010890:1854718-1854813 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT53042 NZ_CP010890:c1854898-1854841 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin