Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1106485..1107074 Replicon chromosome
Accession NZ_CP010827
Organism Corynebacterium singulare strain IBS B52218

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag CSING_RS13275 Protein ID WP_084226171.1
Coordinates 1106485..1106766 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CSING_RS05170 Protein ID WP_042530305.1
Coordinates 1106775..1107074 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSING_RS05150 1102025..1103005 - 981 WP_042530299.1 selenide, water dikinase SelD -
CSING_RS05160 1103160..1104443 + 1284 WP_042530301.1 L-seryl-tRNA(Sec) selenium transferase -
CSING_RS05165 1104444..1106210 + 1767 WP_042530303.1 selenocysteine-specific translation elongation factor -
CSING_RS13275 1106485..1106766 + 282 WP_084226171.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CSING_RS05170 1106775..1107074 + 300 WP_042530305.1 HigA family addiction module antidote protein Antitoxin
CSING_RS05175 1107442..1108260 - 819 WP_042530307.1 hypothetical protein -
CSING_RS05180 1108338..1109555 + 1218 Protein_1037 BCCT family transporter -
CSING_RS05185 1109565..1110362 + 798 WP_042530309.1 zinc transporter ZupT -
CSING_RS05190 1110371..1111291 - 921 WP_042530311.1 DUF808 domain-containing protein -
CSING_RS05195 1111334..1111870 - 537 WP_042530313.1 DUF402 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(8-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10838.28 Da        Isoelectric Point: 10.9953

>T52927 WP_084226171.1 NZ_CP010827:1106485-1106766 [Corynebacterium singulare]
MIQSFADRDTELVWLRRASPRIDSRIHKTANRKLHQLDAAVSLQSLRIPPGNRLEALKGDRRGTYSIRVNQQWRITFRWT
EAGPADVAIEDYH

Download         Length: 282 bp

>T52927 NZ_CP010827:1106485-1106766 [Corynebacterium singulare]
ATGATCCAGTCCTTTGCTGACCGAGACACCGAGCTTGTCTGGTTGCGCCGAGCGTCACCGCGGATCGATTCGAGAATCCA
CAAGACCGCAAATAGAAAACTTCATCAGCTTGATGCGGCGGTTTCCCTGCAATCGCTGCGAATACCGCCGGGCAACCGGT
TGGAAGCTTTGAAAGGCGACCGACGGGGAACATACAGCATTCGTGTCAATCAGCAATGGAGGATTACTTTTCGCTGGACT
GAAGCAGGTCCGGCAGACGTGGCGATAGAGGATTATCACTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11099.76 Da        Isoelectric Point: 5.1327

>AT52927 WP_042530305.1 NZ_CP010827:1106775-1107074 [Corynebacterium singulare]
MSTKLYPPIHPGEVLNEDFIKAFGITQHKLAMAIGVPPRRINEIVHGKRGITADTALRLGKYFGVEPQFWLNLQGRYELE
VAEDSIAEEINSIEPLEVA

Download         Length: 300 bp

>AT52927 NZ_CP010827:1106775-1107074 [Corynebacterium singulare]
ATGAGTACCAAGCTGTATCCGCCAATTCATCCCGGAGAAGTGCTCAATGAGGATTTCATTAAGGCATTCGGGATCACACA
ACATAAGCTGGCCATGGCCATTGGGGTCCCGCCACGCAGGATTAATGAGATTGTCCACGGCAAGCGCGGAATCACCGCAG
ATACTGCGTTGCGGCTAGGAAAGTATTTCGGGGTAGAACCGCAGTTCTGGCTGAACTTGCAAGGAAGATACGAACTCGAG
GTAGCTGAGGACTCTATCGCCGAAGAAATCAACAGTATTGAGCCGCTCGAAGTGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References