Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 1226479..1226699 Replicon chromosome
Accession NZ_CP010816
Organism Escherichia coli strain BL21 (TaKaRa)

Toxin (Protein)


Gene name ldrD Uniprot ID E3PKK3
Locus tag SR36_RS06150 Protein ID WP_000170951.1
Coordinates 1226479..1226586 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 1226636..1226699 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SR36_RS06125 (SR36_06125) 1222325..1223407 + 1083 WP_000804726.1 peptide chain release factor 1 -
SR36_RS06130 (SR36_06130) 1223407..1224240 + 834 WP_000456454.1 peptide chain release factor N(5)-glutamine methyltransferase -
SR36_RS06135 (SR36_06135) 1224237..1224629 + 393 WP_000200373.1 invasion regulator SirB2 -
SR36_RS06140 (SR36_06140) 1224633..1225442 + 810 WP_001257044.1 invasion regulator SirB1 -
SR36_RS06145 (SR36_06145) 1225478..1226332 + 855 WP_000811065.1 3-deoxy-8-phosphooctulonate synthase -
SR36_RS06150 (SR36_06150) 1226479..1226586 - 108 WP_000170951.1 type I toxin-antitoxin system toxin Ldr family protein Toxin
- 1226636..1226699 + 64 - - Antitoxin
SR36_RS06155 (SR36_06155) 1227014..1227121 - 108 WP_000170963.1 small toxic polypeptide LdrB -
SR36_RS06160 (SR36_06160) 1227549..1227656 - 108 WP_000170965.1 type I toxin-antitoxin system toxin Ldr family protein -
SR36_RS06165 (SR36_06165) 1228061..1229161 - 1101 WP_001295620.1 sodium-potassium/proton antiporter ChaA -
SR36_RS06170 (SR36_06170) 1229431..1229661 + 231 WP_001146444.1 putative cation transport regulator ChaB -
SR36_RS06175 (SR36_06175) 1229819..1230514 + 696 WP_012775986.1 glutathione-specific gamma-glutamylcyclotransferase -
SR36_RS06180 (SR36_06180) 1230558..1230911 - 354 WP_001169669.1 DsrE/F sulfur relay family protein YchN -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 3961.74 Da        Isoelectric Point: 9.1413

>T52900 WP_000170951.1 NZ_CP010816:c1226586-1226479 [Escherichia coli]
MTLAQFAMIFWDDLAAPILAGIITAAIVGWWRNRK

Download         Length: 108 bp

>T52900 NZ_CP010816:c1226586-1226479 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGGACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 64 bp

>AT52900 NZ_CP010816:1226636-1226699 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGATTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E3PKK3

Antitoxin

Download structure file

References