Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 796361..796976 | Replicon | chromosome |
| Accession | NZ_CP010812 | ||
| Organism | Vibrio cholerae strain 10432-62 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q9KMG5 |
| Locus tag | VAB027_RS03780 | Protein ID | WP_001162670.1 |
| Coordinates | 796689..796976 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | VAB027_RS03775 | Protein ID | WP_001232701.1 |
| Coordinates | 796361..796678 (-) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| VAB027_RS03735 | 791415..791684 | - | 270 | WP_001114075.1 | DUF4160 domain-containing protein | - |
| VAB027_RS20240 | 791936..792031 | - | 96 | WP_001907607.1 | DUF645 family protein | - |
| VAB027_RS03740 | 792442..792720 | + | 279 | WP_001258569.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| VAB027_RS03745 | 792713..792982 | + | 270 | WP_000277238.1 | type II toxin-antitoxin system YafQ family toxin | - |
| VAB027_RS20150 | 793578..794003 | - | 426 | WP_052724878.1 | hypothetical protein | - |
| VAB027_RS03755 | 794150..794848 | - | 699 | WP_046126203.1 | HAD family phosphatase | - |
| VAB027_RS03760 | 794939..795496 | - | 558 | WP_046126204.1 | GNAT family N-acetyltransferase | - |
| VAB027_RS03765 | 795708..795956 | + | 249 | WP_000213183.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| VAB027_RS03770 | 795946..796236 | + | 291 | WP_000221352.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| VAB027_RS20335 | 796254..796364 | - | 111 | WP_082798255.1 | DUF3265 domain-containing protein | - |
| VAB027_RS03775 | 796361..796678 | - | 318 | WP_001232701.1 | HigA family addiction module antidote protein | Antitoxin |
| VAB027_RS03780 | 796689..796976 | - | 288 | WP_001162670.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| VAB027_RS03785 | 797328..797536 | - | 209 | Protein_732 | DUF3709 domain-containing protein | - |
| VAB027_RS20155 | 797833..798465 | - | 633 | WP_046126205.1 | hypothetical protein | - |
| VAB027_RS19335 | 798718..798999 | - | 282 | WP_080341684.1 | DUF1289 domain-containing protein | - |
| VAB027_RS20245 | 798948..799061 | - | 114 | WP_080341690.1 | acetyltransferase | - |
| VAB027_RS03795 | 799117..799497 | - | 381 | WP_046126206.1 | glyoxalase | - |
| VAB027_RS03800 | 799640..799915 | - | 276 | WP_000436062.1 | hypothetical protein | - |
| VAB027_RS19350 | 800197..800433 | - | 237 | WP_080341691.1 | DUF3709 domain-containing protein | - |
| VAB027_RS03805 | 800715..801050 | - | 336 | WP_046126207.1 | hypothetical protein | - |
| VAB027_RS03815 | 801510..801692 | - | 183 | WP_046126209.1 | DUF645 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 737949..818855 | 80906 | |
| - | inside | Integron | - | - | 741722..820081 | 78359 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11349.95 Da Isoelectric Point: 6.7187
>T52888 WP_001162670.1 NZ_CP010812:c796976-796689 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
Download Length: 288 bp
>T52888 NZ_CP010812:c796976-796689 [Vibrio cholerae]
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11705.63 Da Isoelectric Point: 10.4711
>AT52888 WP_001232701.1 NZ_CP010812:c796678-796361 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART
Download Length: 318 bp
>AT52888 NZ_CP010812:c796678-796361 [Vibrio cholerae]
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGGGAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGCGTACACAGAAATACGGTGAGTAATTTGATTAATGGTGGTGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCAGCGGCATTAGGCAACACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGCAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGGGAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGCGTACACAGAAATACGGTGAGTAATTTGATTAATGGTGGTGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCAGCGGCATTAGGCAACACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGCAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|