Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/RelE-MqsA |
| Location | 784555..785188 | Replicon | chromosome |
| Accession | NZ_CP010812 | ||
| Organism | Vibrio cholerae strain 10432-62 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q9KMA6 |
| Locus tag | VAB027_RS03690 | Protein ID | WP_000843587.1 |
| Coordinates | 784856..785188 (-) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | VAB027_RS03685 | Protein ID | WP_000071008.1 |
| Coordinates | 784555..784869 (-) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| VAB027_RS03640 | 779685..780134 | - | 450 | WP_046126195.1 | GyrI-like domain-containing protein | - |
| VAB027_RS03645 | 780271..780807 | - | 537 | WP_046126196.1 | nucleotidyltransferase family protein | - |
| VAB027_RS03660 | 781051..781272 | - | 222 | WP_046126197.1 | DUF1289 domain-containing protein | - |
| VAB027_RS19295 | 781342..781467 | - | 126 | WP_142741462.1 | DUF3265 domain-containing protein | - |
| VAB027_RS03665 | 781476..781847 | - | 372 | WP_046126198.1 | DUF4440 domain-containing protein | - |
| VAB027_RS03670 | 781994..782482 | - | 489 | WP_046126199.1 | GNAT family N-acetyltransferase | - |
| VAB027_RS03675 | 782614..782961 | - | 348 | WP_000933405.1 | hypothetical protein | - |
| VAB027_RS03680 | 783124..783486 | - | 363 | WP_162484548.1 | DUF4144 domain-containing protein | - |
| VAB027_RS19855 | 783678..783815 | - | 138 | WP_000757220.1 | YHYH domain-containing protein | - |
| VAB027_RS20145 | 784080..784118 | - | 39 | WP_108244118.1 | hypothetical protein | - |
| VAB027_RS19860 | 784134..784261 | - | 128 | Protein_709 | DUF645 family protein | - |
| VAB027_RS03685 | 784555..784869 | - | 315 | WP_000071008.1 | DNA-binding transcriptional regulator | Antitoxin |
| VAB027_RS03690 | 784856..785188 | - | 333 | WP_000843587.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| VAB027_RS03695 | 785404..785769 | - | 366 | WP_046121679.1 | DUF3465 domain-containing protein | - |
| VAB027_RS03700 | 785925..786929 | - | 1005 | WP_046126200.1 | LD-carboxypeptidase | - |
| VAB027_RS03705 | 787233..788153 | + | 921 | WP_001896359.1 | IS5-like element ISVch8 family transposase | - |
| VAB027_RS03710 | 788131..788655 | - | 525 | WP_142741359.1 | hypothetical protein | - |
| VAB027_RS03715 | 788803..789540 | - | 738 | WP_046126202.1 | hypothetical protein | - |
| VAB027_RS03720 | 789683..790031 | - | 349 | Protein_717 | GrpB family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 737949..818855 | 80906 | |
| - | flank | IS/Tn | - | - | 787233..788153 | 920 | |
| - | inside | Integron | - | - | 741722..820081 | 78359 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 13005.95 Da Isoelectric Point: 9.9244
>T52884 WP_000843587.1 NZ_CP010812:c785188-784856 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS
Download Length: 333 bp
>T52884 NZ_CP010812:c785188-784856 [Vibrio cholerae]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA
Antitoxin
Download Length: 105 a.a. Molecular weight: 11696.20 Da Isoelectric Point: 6.7600
>AT52884 WP_000071008.1 NZ_CP010812:c784869-784555 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL
Download Length: 315 bp
>AT52884 NZ_CP010812:c784869-784555 [Vibrio cholerae]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCTGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCTGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|