Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1080708..1081303 Replicon chromosome
Accession NZ_CP010554
Organism Rugosibacter aromaticivorans strain Ca6

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag PG1C_RS05475 Protein ID WP_202636391.1
Coordinates 1081022..1081303 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PG1C_RS05470 Protein ID WP_202636390.1
Coordinates 1080708..1081010 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PG1C_RS05445 1076122..1076466 - 345 WP_202636385.1 hypothetical protein -
PG1C_RS05450 1076609..1079074 - 2466 WP_202636386.1 DUF3987 domain-containing protein -
PG1C_RS05455 1079263..1079469 - 207 WP_202636387.1 AlpA family phage regulatory protein -
PG1C_RS05460 1079546..1080265 - 720 WP_202636388.1 hypothetical protein -
PG1C_RS05465 1080278..1080445 - 168 WP_202636389.1 hypothetical protein -
PG1C_RS05470 1080708..1081010 - 303 WP_202636390.1 HigA family addiction module antidote protein Antitoxin
PG1C_RS05475 1081022..1081303 - 282 WP_202636391.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PG1C_RS05480 1081386..1082591 - 1206 WP_202636392.1 site-specific integrase -
PG1C_RS05485 1082913..1085576 - 2664 WP_202636393.1 Rne/Rng family ribonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-66)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10655.07 Da        Isoelectric Point: 7.8610

>T52797 WP_202636391.1 NZ_CP010554:c1081303-1081022 [Rugosibacter aromaticivorans]
MTIRSFRCADTLALYEGRKPKRFRNIEAVAERKLQMLDDAVELRDLASPPGNRLEALGGNRQGQHSIRINNQWRVCFVWA
DNGAADVEIVDYH

Download         Length: 282 bp

>T52797 NZ_CP010554:c1081303-1081022 [Rugosibacter aromaticivorans]
ATGACTATCCGCTCTTTCCGATGTGCCGACACACTGGCGCTTTATGAAGGCCGCAAGCCGAAGCGTTTTCGTAATATCGA
AGCCGTTGCCGAACGCAAGCTGCAAATGCTGGATGATGCTGTTGAATTGCGAGACTTGGCATCGCCACCCGGCAACCGGC
TGGAAGCATTGGGCGGCAACCGGCAGGGGCAACATAGCATCCGCATCAATAACCAATGGCGCGTGTGCTTTGTGTGGGCA
GATAACGGTGCGGCGGATGTCGAGATTGTCGATTACCACTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11341.04 Da        Isoelectric Point: 8.6220

>AT52797 WP_202636390.1 NZ_CP010554:c1081010-1080708 [Rugosibacter aromaticivorans]
MATNKMRAIHPGEIIREEYLAPLNMSPHALAIELRVPATRLNDIVRERRAISPDTALRLARYFGTTGQFWLNLQGTFDLK
QAESELGQRINQEVKPLEAA

Download         Length: 303 bp

>AT52797 NZ_CP010554:c1081010-1080708 [Rugosibacter aromaticivorans]
ATGGCAACGAACAAGATGAGAGCAATACATCCCGGCGAAATTATCCGCGAGGAATATCTCGCCCCCTTGAACATGAGTCC
GCATGCGCTGGCGATTGAGCTGCGCGTACCCGCAACACGCCTCAATGACATTGTGCGCGAACGCCGTGCCATAAGCCCGG
ATACCGCTTTGCGGCTGGCAAGATACTTCGGCACCACGGGGCAATTCTGGCTGAACCTGCAAGGCACGTTTGACCTGAAA
CAGGCAGAGAGCGAGCTAGGGCAACGGATCAATCAGGAAGTGAAGCCGTTAGAGGCGGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References